Journal Article

Digital Biosensing by Foundry-Fabricated Graphene Sensors

Nokes, Jolie, Walker, Amy, Kyaw, Jayla, Pan, Deng, Goldsmith, Brett R., Lerner, Jeremy, Barron, Francie, Lerner, Mitchell, Locascio, Lauren, Gao, Yingning, Afsahi, Savannah, Shue, Angela

2019

Overview

The prevailing philosophy in biological testing has been to focus on simple tests with easy to interpret information such as ELISA or lateral flow assays. At the same time, there has been a decades long understanding in device physics and nanotechnology that electrical approaches have the potential to drastically improve the quality, speed, and cost of biological testing provided that computational resources are available to analyze the resulting complex data. This concept can be conceived of as “the internet of biology” in the same way miniaturized electronic sensors have enabled “the internet of things.” It is well established in the nanotechnology literature that techniques such as field effect biosensing are capable of rapid and flexible biological testing. Until now, access to this new technology has been limited to academic researchers focused on bioelectronic devices and their collaborators. Here we show that this capability is retained in an industrially manufactured device, opening access to this technology generally. Access to this type of production opens the door for rapid deployment of nanoelectronic sensors outside the research space. The low power and resource usage of these biosensors enables biotech engineers to gain immediate control over precise biological and environmental data.

• Publisher: Nature Publishing Group UK,Nature Publishing Group
• Subject: 142/126 / 631/61/32 / 639/925/918/1052 / 639/925/927/356 / 9/10 / Biosensors / Computer applications / Enzyme-linked immunosorbent assay / Humanities and Social Sciences / Internet of Things / multidisciplinary / Nanotechnology / Science / Science (multidisciplinary) / Sensors