Asset Details
Do you wish to reserve the book?
The maternal microbiome modulates fetal neurodevelopment in mice
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
The maternal microbiome modulates fetal neurodevelopment in mice
Do you wish to request the book?
The maternal microbiome modulates fetal neurodevelopment in mice
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
The maternal microbiome modulates fetal neurodevelopment in mice
2020
Overview
‘Dysbiosis’ of the maternal gut microbiome, in response to challenges such as infection
1
, altered diet
2
and stress
3
during pregnancy, has been increasingly associated with abnormalities in brain function and behaviour of the offspring
4
. However, it is unclear whether the maternal gut microbiome influences neurodevelopment during critical prenatal periods and in the absence of environmental challenges. Here we investigate how depletion and selective reconstitution of the maternal gut microbiome influences fetal neurodevelopment in mice. Embryos from antibiotic-treated and germ-free dams exhibited reduced brain expression of genes related to axonogenesis, deficient thalamocortical axons and impaired outgrowth of thalamic axons in response to cell-extrinsic factors. Gnotobiotic colonization of microbiome-depleted dams with a limited consortium of bacteria prevented abnormalities in fetal brain gene expression and thalamocortical axonogenesis. Metabolomic profiling revealed that the maternal microbiome regulates numerous small molecules in the maternal serum and the brains of fetal offspring. Select microbiota-dependent metabolites promoted axon outgrowth from fetal thalamic explants. Moreover, maternal supplementation with these metabolites abrogated deficiencies in fetal thalamocortical axons. Manipulation of the maternal microbiome and microbial metabolites during pregnancy yielded adult offspring with altered tactile sensitivity in two aversive somatosensory behavioural tasks, but no overt differences in many other sensorimotor behaviours. Together, our findings show that the maternal gut microbiome promotes fetal thalamocortical axonogenesis, probably through signalling by microbially modulated metabolites to neurons in the developing brain.
Small molecules that arise from the maternal gut microbiome in pregnant dams promote fetal thalamocortical axonogenesis in their offspring.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 13/1
/ 13/106
/ 13/51
/ 14/19
/ 14/63
/ 38
/ 38/39
/ 38/77
/ 38/90
/ 38/91
/ 64
/ 64/60
/ 82/58
/ Animals
/ Axons
/ Brain
/ Cerebral Cortex - embryology
/ Cerebral Cortex - metabolism
/ Dams
/ Embryos
/ Explants
/ Female
/ Fetuses
/ Gastrointestinal Microbiome - physiology
/ Germfree
/ Humanities and Social Sciences
/ Male
/ Mice
/ Mothers
/ Pregnancy Complications - blood
/ Pregnancy Complications - microbiology
/ Pregnancy Complications - pathology
/ Principal Component Analysis
/ Science
/ Thalamus
