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The gut commensal Blautia maintains colonic mucus function under low-fiber consumption through secretion of short-chain fatty acids
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The gut commensal Blautia maintains colonic mucus function under low-fiber consumption through secretion of short-chain fatty acids
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Journal Article
The gut commensal Blautia maintains colonic mucus function under low-fiber consumption through secretion of short-chain fatty acids
2024
Overview
Beneficial gut bacteria are indispensable for developing colonic mucus and fully establishing its protective function against intestinal microorganisms. Low-fiber diet consumption alters the gut bacterial configuration and disturbs this microbe-mucus interaction, but the specific bacteria and microbial metabolites responsible for maintaining mucus function remain poorly understood. By using human-to-mouse microbiota transplantation and ex vivo analysis of colonic mucus function, we here show as a proof-of-concept that individuals who increase their daily dietary fiber intake can improve the capacity of their gut microbiota to prevent diet-mediated mucus defects. Mucus growth, a critical feature of intact colonic mucus, correlated with the abundance of the gut commensal
Blautia
, and supplementation of
Blautia coccoides
to mice confirmed its mucus-stimulating capacity. Mechanistically,
B. coccoides
stimulated mucus growth through the production of the short-chain fatty acids propionate and acetate via activation of the short-chain fatty acid receptor Ffar2, which could serve as a new target to restore mucus growth during mucus-associated lifestyle diseases.
Here, the authors show that elevating fiber intake in humans alters their gut microbiota, which, upon transplantation into mice, enhances intestinal mucus function, and identify a crucial role played by the commensal bacterium
Blautia
and its fermentation products.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 14/19
/ 38/23
/ 38/39
/ 45/77
/ 49/90
/ 64/60
/ 82/58
/ Adult
/ Animals
/ Bacteria
/ Blautia
/ Diet
/ Fatty Acids, Volatile - metabolism
/ Fecal Microbiota Transplantation
/ Female
/ Humanities and Social Sciences
/ Humans
/ Intestinal Mucosa - metabolism
/ Intestinal Mucosa - microbiology
/ Male
/ Mice
/ Mucus
/ Receptors, G-Protein-Coupled - genetics
/ Receptors, G-Protein-Coupled - metabolism
/ Science
