Journal Article

Cigarette smoking, alcohol intake, and thyroid cancer risk: a pooled analysis of five prospective studies in the United States

Freeman, Laura E. Beane, Linet, Martha S., de González, Amy Berrington, Purdue, Mark P., Schairer, Catherine, Church, Timothy R., Park, Yikyung, Check, David P., Kitahara, Cari M.

2012

Overview

Objective: We examined the associations between cigarette smoking, alcohol intake, and thyroid cancer risk in a pooled analysis of five prospective studies. Methods: Data from five prospective U.S. studies were standardized and then combined into one aggregate dataset (384,433 men and 361,664 women). Pooled hazard ratios (HR) and 95 % confidence intervals (CI) for thyroid cancer were estimated from mutually adjusted models of cigarette smoking and alcohol intake, which were additionally adjusted for age, sex, education, race, marital status, body mass index, and cohort. Results: Over follow-up, 1,003 incident thyroid cancer cases (335 men and 668 women) were identified. Compared to never smokers, current smoking was associated with reduced risk of thyroid cancer (HR = 0.68, 95 % CI 0.55—0.85); this association was slightly stronger among non-drinkers (HR = 0.46, 95 % CI 0.29—0.74). No reduction in risk was observed for former, compared to never, smokers. Greater smoking intensity, duration, and pack-years were associated with further reductions in risk among former and current smokers. Alcohol intake was also inversely associated with thyroid cancer risk (≥7 drinks/week versus 0, HR = 0.72, 95 % CI 0.58—0.90, p trend = 0.002). Inverse associations with smoking and alcohol were more pronounced for papillary versus follicular tumors. Conclusion: The results of this pooled analysis suggest that both cigarette smoking and alcohol consumption are associated with reduced risks of papillary thyroid cancer and, possibly, follicular thyroid cancer.

• Publisher: Springer,Springer Netherlands,Springer Nature B.V
• Subject: Adult / Age / Aged / Alcohol / Alcohol drinking / Alcohol Drinking - adverse effects / Alcohol use / Alcohols / Biomedical and Life Sciences / Biomedicine / Body mass index / Cancer / Cancer Research / Carcinoma - epidemiology / Carcinoma - etiology / Carcinoma, Papillary / Cigarette smoking / Cigarettes / Confidence Intervals / Education / Epidemiology / Female / Hematology / Humans / Male / Marriage / Medical screening / Men / Middle Aged / Oncology / Original Paper / Papillae / Predisposing factors / Prospective Studies / Public Health / Questionnaires / Risk Factors / Risk reduction / Sex education / Skin cancer / Smoking / Smoking - adverse effects / Smoking cessation / Thyroid / Thyroid cancer / Thyroid Cancer, Papillary / Thyroid Neoplasms - epidemiology / Thyroid Neoplasms - etiology / Trends / Tumors / United States - epidemiology / Womens health