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Neuroinflammation causes mitral cell dysfunction and olfactory impairment in a multiple sclerosis model
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Neuroinflammation causes mitral cell dysfunction and olfactory impairment in a multiple sclerosis model
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Journal Article
Neuroinflammation causes mitral cell dysfunction and olfactory impairment in a multiple sclerosis model
2025
Overview
Background
Olfactory dysfunction is an underestimated symptom in multiple sclerosis (MS). Here, we examined the pathogenic mechanisms underlying inflammation-induced dysfunction of the olfactory bulb using the animal model of MS, experimental autoimmune encephalomyelitis (EAE).
Results
Reduced olfactory function in EAE was associated with the degeneration of short-axon neurons, immature neurons, and both mitral and tufted cells, along with their synaptic interactions and axonal repertoire. To dissect the mechanisms underlying the susceptibility of mitral cells, the main projection neurons of the olfactory bulb, we profiled their responses to neuroinflammation by single-nucleus RNA sequencing followed by functional validation. Neuroinflammation resulted in the induction of potassium channel transcripts in mitral cells, which was reflected in increased halothane-induced outward currents of these cells, likely contributing to the impaired olfaction in EAE animals.
Conclusion
This study reveals the crucial role of mitral cells and their potassium channel activity in the olfactory bulb during EAE, thereby enhancing our understanding of neuroinflammation-induced neurodegeneration in MS.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Animals
/ Behavior
/ Biomedical and Life Sciences
/ Cells
/ Encephalomyelitis, Autoimmune, Experimental - complications
/ Encephalomyelitis, Autoimmune, Experimental - pathology
/ Experimental allergic encephalomyelitis
/ Experimental autoimmune encephalomyelitis
/ Female
/ Mice
/ Multiple Sclerosis - complications
/ Multiple Sclerosis - pathology
/ Neuroinflammatory Diseases - pathology
/ Neurons
/ Odors
/ Olfaction Disorders - etiology
/ Olfaction Disorders - pathology
/ Olfactory Bulb - physiopathology
