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Poly(amino acid) based fibrous membranes with tuneable in vivo biodegradation
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Poly(amino acid) based fibrous membranes with tuneable in vivo biodegradation
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Journal Article
Poly(amino acid) based fibrous membranes with tuneable in vivo biodegradation
2021
Overview
In this work two types of biodegradable polysuccinimide-based, electrospun fibrous membranes are presented. One contains disulfide bonds exhibiting a shorter (3 days)
in vivo
biodegradation time, while the other one has alkyl crosslinks and a longer biodegradation time (more than 7 days). According to the mechanical measurements, the tensile strength of the membranes is comparable to those of soft the connective tissues and visceral tissues. Furthermore, the suture retention test suggests, that the membranes would withstand surgical handling and
in vivo
fixation. The
in vivo
biocompatibility study demonstrates how membranes undergo
in vivo
hydrolysis and by the 3
rd
day they become poly(aspartic acid) fibrous membranes, which can be then enzymatically degraded. After one week, the disulfide crosslinked membranes almost completely degrade, while the alkyl-chain crosslinked ones mildly lose their integrity as the surrounding tissue invades them. Histopathology revealed mild acute inflammation, which diminished to a minimal level after seven days.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
