Journal Article

Analytical performance of aPROMISE: automated anatomic contextualization, detection, and quantification of 18FDCFPyL (PSMA) imaging for standardized reporting

Nickols, Nicholas G., Probst, Stephan, Bjartell, Anders, Eiber, Mathias, Sahlstedt, Hannicka, Brynolfsson, Johan, Rettig, Matthew, Anand, Aseem, Johnsson, Kerstin, Morris, Michael J.

2022

Overview

Purpose The application of automated image analyses could improve and facilitate standardization and consistency of quantification in [ 18 F]DCFPyL (PSMA) PET/CT scans. In the current study, we analytically validated aPROMISE, a software as a medical device that segments organs in low-dose CT images with deep learning, and subsequently detects and quantifies potential pathological lesions in PSMA PET/CT. Methods To evaluate the deep learning algorithm, the automated segmentations of the low-dose CT component of PSMA PET/CT scans from 20 patients were compared to manual segmentations. Dice scores were used to quantify the similarities between the automated and manual segmentations. Next, the automated quantification of tracer uptake in the reference organs and detection and pre-segmentation of potential lesions were evaluated in 339 patients with prostate cancer, who were all enrolled in the phase II/III OSPREY study. Three nuclear medicine physicians performed the retrospective independent reads of OSPREY images with aPROMISE. Quantitative consistency was assessed by the pairwise Pearson correlations and standard deviation between the readers and aPROMISE. The sensitivity of detection and pre-segmentation of potential lesions was evaluated by determining the percent of manually selected abnormal lesions that were automatically detected by aPROMISE. Results The Dice scores for bone segmentations ranged from 0.88 to 0.95. The Dice scores of the PSMA PET/CT reference organs, thoracic aorta and liver, were 0.89 and 0.97, respectively. Dice scores of other visceral organs, including prostate, were observed to be above 0.79. The Pearson correlation for blood pool reference was higher between any manual reader and aPROMISE, than between any pair of manual readers. The standard deviations of reference organ uptake across all patients as determined by aPROMISE (SD = 0.21 blood pool and SD = 1.16 liver) were lower compared to those of the manual readers. Finally, the sensitivity of aPROMISE detection and pre-segmentation was 91.5% for regional lymph nodes, 90.6% for all lymph nodes, and 86.7% for bone in metastatic patients. Conclusion In this analytical study, we demonstrated the segmentation accuracy of the deep learning algorithm, the consistency in quantitative assessment across multiple readers, and the high sensitivity in detecting potential lesions. The study provides a foundational framework for clinical evaluation of aPROMISE in standardized reporting of PSMA PET/CT.

• Publisher: Springer Berlin Heidelberg,Springer Nature B.V
• Subject: Algorithms / Aorta / Automation / Blood / Cardiology / Clinical Medicine / Computed tomography / Consistency / Deep learning / Fluorine isotopes / Humans / Image Processing, Computer-Assisted / Image segmentation / Imaging / Klinisk medicin / Lesions / Liver / Lymph nodes / Lymphatic system / Machine learning / Male / Mathematical analysis / Medical and Health Sciences / Medical imaging / Medicin och hälsovetenskap / Medicine / Medicine & Public Health / Metastases / Nuclear Medicine / Oncology / Oncology – Genitourinary / Organs / Original / Original Article / Orthopedics / Patients / Physicians / Positron emission / Positron Emission Tomography Computed Tomography - methods / Prostate / Prostate - pathology / Prostate cancer / Prostatic Neoplasms - diagnostic imaging / Prostatic Neoplasms - pathology / Radiologi och bildbehandling / Radiology / Radiology and Medical Imaging / Retrospective Studies / Standard deviation / Standardization / Thorax / Tomography