Asset Details
Do you wish to reserve the book?
Sublingual immunization with a subunit influenza vaccine elicits comparable systemic immune response as intramuscular immunization, but also induces local IgA and TH17 responses
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Sublingual immunization with a subunit influenza vaccine elicits comparable systemic immune response as intramuscular immunization, but also induces local IgA and TH17 responses
Do you wish to request the book?
Sublingual immunization with a subunit influenza vaccine elicits comparable systemic immune response as intramuscular immunization, but also induces local IgA and TH17 responses
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Sublingual immunization with a subunit influenza vaccine elicits comparable systemic immune response as intramuscular immunization, but also induces local IgA and TH17 responses
2014
Overview
•This paper provides a novel and original strategy to develop subunit vaccines for sublingual delivery.•Sublingual administration of subunit influenza Ags adjuvanted with LTK63 elicited comparable antibody titers to intramuscular immunization.•The sublingual delivery elicited Ag-specific mucosal IgA with neutralizing activity, contributing to anti-influenza defenses.•The mucosal route in combination with LTK63 elicited an Ag-specific Th17 response that might play a role in protection against influenza.•Sublingual delivery of an adjuvanted subunit influenza vaccine could be an effective alternative to conventional intramuscular vaccines.
Influenza is a vaccine-preventable disease that remains a major health problem world-wide. Needle and syringe are still the primary delivery devices, and injection of liquid vaccine into the muscle is still the primary route of immunization. Vaccines could be more convenient and effective if they were delivered by the mucosal route. Elicitation of systemic and mucosal innate and adaptive immune responses, such as pathogen neutralizing antibodies (including mucosal IgA at the site of pathogen entry) and CD4+ T-helper cells (especially the Th17 subset), have a critical role in vaccine-mediated protection. In the current study, a sublingual subunit influenza vaccine formulated with or without mucosal adjuvant was evaluated for systemic and mucosal immunogenicity and compared to intranasal and intramuscular vaccination. Sublingual administration of adjuvanted influenza vaccine elicited comparable antibody titers to those elicited by intramuscular immunization with conventional influenza vaccine. Furthermore, influenza-specific Th17 cells or neutralizing mucosal IgA were detected exclusively after mucosal immunization.
Publisher
Elsevier Ltd,Elsevier,Elsevier Limited
Subject
/ Adjuvants, Immunologic - administration & dosage
/ Animals
/ Antibodies, Neutralizing - immunology
/ Antibodies, Viral - immunology
/ Biological and medical sciences
/ Female
/ Fundamental and applied biological sciences. Psychology
/ Hemagglutination Inhibition Tests
/ Humans
/ Immunoglobulin A - immunology
/ Influenza A Virus, H1N1 Subtype
/ Influenza Vaccines - administration & dosage
/ Mice
/ muscles
/ Orthomyxoviridae Infections - prevention & control
/ Rodents
/ Studies
/ Vaccines
/ Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
