Journal Article

Regulation of myelopoiesis by proinflammatory cytokines in infectious diseases

Nagai, Taro, Xu, Mingli, Orii, Naoko, Mizoguchi, Izuru, Hasegawa, Hideaki, Chiba, Yukino, Miyamoto, Yasunori, Yoshimoto, Takayuki, Sugahara, Miyaka, Ohashi, Mio, Owaki, Toshiyuki

2018

Overview

Hematopoiesis is hierarchically orchestrated by a very small population of hematopoietic stem cells (HSCs) that reside in the bone-marrow niche and are tightly regulated to maintain homeostatic blood production. HSCs are predominantly quiescent, but they enter the cell cycle in response to inflammatory signals evoked by severe systemic infection or injury. Thus, hematopoietic stem and progenitor cells (HSPCs) can be activated by pathogen recognition receptors and proinflammatory cytokines to induce emergency myelopoiesis during infection. This emergency myelopoiesis counterbalances the loss of cells and generates lineage-restricted hematopoietic progenitors, eventually replenishing mature myeloid cells to control the infection. Controlled generation of such signals effectively augments host defense, but dysregulated stimulation by these signals is harmful to HSPCs. Such hematopoietic failure often results in blood disorders including chronic inflammatory diseases and hematological malignancies. Recently, we found that interleukin (IL)-27, one of the IL-6/IL-12 family cytokines, has a unique ability to directly act on HSCs and promote their expansion and differentiation into myeloid progenitors. This process resulted in enhanced production of neutrophils by emergency myelopoiesis during the blood-stage mouse malaria infection. In this review, we summarize recent advances in the regulation of myelopoiesis by proinflammatory cytokines including type I and II interferons, IL-6, IL-27, granulocyte colony-stimulating factor, macrophage colony-stimulating factor, and IL-1 in infectious diseases.

• Publisher: Springer International Publishing,Springer Nature B.V
• Subject: Animals / Biochemistry / Biomedical and Life Sciences / Biomedicine / Blood / Bone marrow / Cell Biology / Cell cycle / Cell Cycle - genetics / Cell Cycle - immunology / Cell Differentiation / Cell Proliferation / Cells (biology) / Colonies / Colony-stimulating factor / Control / Counterbalances / Cytokines / Disseminated infection / Emergencies / Gene Expression Regulation - immunology / Granulocyte colony-stimulating factor / Granulocyte Colony-Stimulating Factor - genetics / Granulocyte Colony-Stimulating Factor - immunology / Granulocyte-macrophage colony-stimulating factor / hematologic diseases / Hematologic Neoplasms - genetics / Hematologic Neoplasms - immunology / Hematologic Neoplasms - pathology / Hematological diseases / Hematopoiesis / Hematopoietic stem cells / Hemopoiesis / Humans / Infections / Infectious diseases / Inflammatory diseases / Interferon / interferons / Interferons - genetics / Interferons - immunology / Interleukin 1 / Interleukin 12 / Interleukin 27 / Interleukin 6 / Interleukin-1 - genetics / Interleukin-1 - immunology / Interleukin-6 - genetics / Interleukin-6 - immunology / Interleukins - genetics / Interleukins - immunology / Leukocytes (neutrophilic) / Life Sciences / macrophage colony-stimulating factor / Macrophage Colony-Stimulating Factor - genetics / Macrophage Colony-Stimulating Factor - immunology / Malaria / Malaria - genetics / Malaria - immunology / Malaria - parasitology / Malaria - pathology / Malignancy / Mice / Myeloid cells / Myeloid Progenitor Cells - immunology / Myeloid Progenitor Cells - parasitology / Myeloid Progenitor Cells - pathology / Myelopoiesis / Myelopoiesis - genetics / Myelopoiesis - immunology / neutrophils / Neutrophils - immunology / Neutrophils - parasitology / Neutrophils - pathology / pathogens / Plasmodium berghei - growth & development / Plasmodium berghei - immunology / Progenitor cells / Receptors / Review / Rodents / Signal generation / Stem cell transplantation / Stem cells / Vector-borne diseases