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Hematopoietic effect of echinochrome on phenylhydrazine-induced hemolytic anemia in rats

by Mohamed, Ayman S. , Ahmed, Salma H. A. , Ali, Sara B. , Damanhory, Ahmed A. , Metawee, Mostafa E. , Lotfy, Bassant M. M. , El-Shehry, Mona S. E. F. , Atia, Tarek , Sakr, Hader I. , Mousa, Mohamed R. , Amrymi, Rafa A. , Qutb, Sarah A.

in Acids / Alkaline phosphatase / Anemia / Anemia, Hemolytic - chemically induced / Animals / Antioxidants / Antioxidants - pharmacology / Aspartate / Bilirubin / Biochemistry / Chromatography / Creatinine / Echinochrome / Erythrocytes / Ethylenediaminetetraacetic acid / gamma-Glutamyltransferase - pharmacology / Glutathione / Glutathione transferase / Glutathione Transferase - adverse effects / Health aspects / Hemoglobin / Hemolytic Anemia / Histology / Hydrazine / Inflammation / Kidneys / Laboratory animals / Lipid peroxidation / Liver / Metabolic Sciences / Molecular Biology / Nitric oxide / Oxidative Stress / Phenylhydrazine / Phenylhydrazines - adverse effects / Phosphatases / Pigments / Rats / Soliman, Mohamed / Urea / Uric acid / γ-Glutamyltransferase

2023

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Hematopoietic effect of echinochrome on phenylhydrazine-induced hemolytic anemia in rats

2023

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Hematopoietic effect of echinochrome on phenylhydrazine-induced hemolytic anemia in rats

2023

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Journal Article

Hematopoietic effect of echinochrome on phenylhydrazine-induced hemolytic anemia in rats

Mohamed, Ayman S.,

Ahmed, Salma H. A.,

Ali, Sara B.,

Damanhory, Ahmed A.,

Metawee, Mostafa E.,

Lotfy, Bassant M. M.,

El-Shehry, Mona S. E. F.,

Atia, Tarek,

Sakr, Hader I.,

Mousa, Mohamed R.,

Amrymi, Rafa A.,

Qutb, Sarah A.

2023

Overview

Hemolytic anemia (HA) is a serious health condition resulting from reduced erythrocytes' average life span. Echinochrome (Ech) is a dark-red pigment found in shells and spines of sea urchins. Studying the potential therapeutic effect of Ech on phenylhydrazine (PHZ)-induced HA in rats. Eighteen rats were divided into three groups ( = 6): the control group, the phenylhydrazine-induced HA group and the Ech group, injected intraperitoneally with PHZ and supplemented with oral Ech daily for 6 days. Ech resulted in a considerable increase in RBCs, WBCs, and platelets counts, hemoglobin, reduced glutathione, catalase, and glutathione-S-transferase levels, and a significant decrease in aspartate & alanine aminotransferases, alkaline phosphatase, gamma-glutamyl transferase, bilirubin, creatinine, urea, urate, malondialdehyde & nitric oxide levels in anemic rats. Histopathological examination of liver and kidney tissue samples showed marked improvement. Ech ameliorated phenylhydrazine-induced HA with a hepatorenal protective effect owing to its anti-inflammatory and antioxidant properties.

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Publisher

PeerJ. Ltd,PeerJ, Inc,PeerJ Inc

Subject

Acids

/ Alkaline phosphatase

/ Anemia

/ Anemia, Hemolytic - chemically induced

/ Animals

/ Antioxidants

/ Antioxidants - pharmacology