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Somatostatin cells regulate sensory response fidelity via subtractive inhibition in olfactory cortex
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Somatostatin cells regulate sensory response fidelity via subtractive inhibition in olfactory cortex
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Journal Article
Somatostatin cells regulate sensory response fidelity via subtractive inhibition in olfactory cortex
2015
Overview
This study shows how somatostatin (SOM)-expressing interneurons contribute to odor coding in mouse olfactory cortex. Odor-tuned SOM cells regulate neuronal output through a purely subtractive operation that is independent of odor identity or intensity. This operation enhances the salience of odor-evoked activity without changing cortical odor tuning.
Diverse types of local GABAergic interneurons shape the cortical representation of sensory information. Here we show how somatostatin-expressing interneurons (SOM cells) contribute to odor coding in mouse olfactory cortex. We find that odor-tuned SOM cells regulate principal cells through a purely subtractive operation that is independent of odor identity or intensity. This operation enhances the salience of odor-evoked activity without changing cortical odor tuning. SOM cells inhibit both principal cells and fast-spiking interneurons, indicating that subtractive inhibition reflects the interplay of multiple classes of interneurons.
Publisher
Nature Publishing Group US,Nature Publishing Group
