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Nanoscale coordination polymers induce immunogenic cell death by amplifying radiation therapy mediated oxidative stress
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Nanoscale coordination polymers induce immunogenic cell death by amplifying radiation therapy mediated oxidative stress
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Journal Article
Nanoscale coordination polymers induce immunogenic cell death by amplifying radiation therapy mediated oxidative stress
2021
Overview
Radiation therapy can potentially induce immunogenic cell death, thereby priming anti-tumor adaptive immune responses. However, radiation-induced systemic immune responses are very rare and insufficient to meet clinical needs. Here, we demonstrate a synergetic strategy for boosting radiation-induced immunogenic cell death by constructing gadolinium-hemin based nanoscale coordination polymers to simultaneously perform X-ray deposition and glutathione depletion. Subsequently, immunogenic cell death is induced by sensitized radiation to potentiate checkpoint blockade immunotherapies against primary and metastatic tumors. In conclusion, nanoscale coordination polymers-sensitized radiation therapy exhibits biocompatibility and therapeutic efficacy in preclinical cancer models, and has the potential for further application in cancer radio-immunotherapy.
Radiotherapy has the potential to induce immunogenic cell death (ICD), however radiation-induced immune responses are often limited. Here the authors design gadolinium-based nanoscale coordination polymers to amplify radiation-mediated oxidative stress, promoting ICD and anti-tumor immune responses.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/21
/ 13/31
/ 13/51
/ 14/19
/ 147/135
/ 59/57
/ 631/250
/ 631/67
/ 631/92
/ Animals
/ Cancer
/ Cell Line, Tumor - transplantation
/ Combined Modality Therapy - methods
/ Coordination Complexes - administration & dosage
/ Coordination Complexes - chemistry
/ Female
/ Gadolinium - administration & dosage
/ Hemin
/ Hemin - administration & dosage
/ Humanities and Social Sciences
/ Humans
/ Immunogenic Cell Death - drug effects
/ Immunogenic Cell Death - radiation effects
/ Mice
/ Nanoparticles - administration & dosage
/ Oxidative Stress - drug effects
/ Oxidative Stress - immunology
/ Oxidative Stress - radiation effects
/ Polymers
/ Priming
/ Radioimmunotherapy - methods
/ Science
/ Tumors
