Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Genetic and epigenetic intratumor heterogeneity impacts prognosis of lung adenocarcinoma

by Zhao, Wei , Wedge, David C. , Wang, Mingyi , Sampson, Joshua , Pesatori, Angela C. , Shi, Jianxin , Landi, Maria Teresa , Zhang, Tongwu , Hicks, Belynda , Caporaso, Neil E. , Jones, Kristine , Hua, Xing , Zhu, Bin , Consonni, Dario , Song, Lei

in 45 / 45/23 / 45/61 / 631/67/1612 / 631/67/2329 / 631/67/69 / Adenocarcinoma / Adenocarcinoma of Lung - genetics / Aged / Aged, 80 and over / Copy number / CpG Islands - genetics / Deoxyribonucleic acid / DNA / DNA Copy Number Variations / DNA methylation / DNA Methylation - genetics / Epigenesis, Genetic / Epigenetics / Evolution, Molecular / Female / Gene mapping / Genes / Genetic Heterogeneity / Heterogeneity / Humanities and Social Sciences / Humans / Kaplan-Meier Estimate / Lung cancer / Lung Neoplasms - genetics / Male / Mapping / Middle Aged / multidisciplinary / Mutation / Mutation - genetics / Polymorphism, Single Nucleotide - genetics / Prognosis / Science / Science (multidisciplinary) / Statistical methods / Treatment Outcome / Tumor suppressor genes / Tumors

2020

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Genetic and epigenetic intratumor heterogeneity impacts prognosis of lung adenocarcinoma

2020

Confirm

Do you wish to request the book?

Genetic and epigenetic intratumor heterogeneity impacts prognosis of lung adenocarcinoma

2020

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Genetic and epigenetic intratumor heterogeneity impacts prognosis of lung adenocarcinoma

Zhao, Wei,

Wedge, David C.,

Wang, Mingyi,

Sampson, Joshua,

Pesatori, Angela C.,

Shi, Jianxin,

Landi, Maria Teresa,

Zhang, Tongwu,

Hicks, Belynda,

Caporaso, Neil E.,

Jones, Kristine,

Hua, Xing,

Zhu, Bin,

Consonni, Dario,

Song, Lei

2020

Overview

Intratumor heterogeneity (ITH) of genomic alterations may impact prognosis of lung adenocarcinoma (LUAD). Here, we investigate ITH of somatic copy number alterations (SCNAs), DNA methylation, and point mutations in lung cancer driver genes in 292 tumor samples from 84 patients with LUAD. LUAD samples show substantial SCNA and methylation ITH, and clonal architecture analyses present congruent evolutionary trajectories for SCNAs and DNA methylation aberrations. Methylation ITH mapping to gene promoter areas or tumor suppressor genes is low. Moreover, ITH composed of genetic and epigenetic mechanisms altering the same cancer driver genes is shown in several tumors. To quantify ITH for valid statistical association analyses, we develope an average pairwise ITH index (APITH), which does not depend on the number of samples per tumor. Both APITH indexes for SCNAs and methylation aberrations show significant associations with poor prognosis. This study further establishes the important clinical implications of genetic and epigenetic ITH in LUAD. Many tumors are known to be heterogeneous. Here, the authors examined multiple samples from 84 patients with lung adenocarcinoma and demonstrate that the intratumor heterogeneity of methylation and copy number associates with poor prognosis.

Share this book

Add to My Shelf

Publisher

Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio

Subject

/ 45/23

/ 45/61

/ Adenocarcinoma of Lung - genetics