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Hemoglobin in the blood acts as a chemosensory signal via the mouse vomeronasal system
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Hemoglobin in the blood acts as a chemosensory signal via the mouse vomeronasal system
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Journal Article
Hemoglobin in the blood acts as a chemosensory signal via the mouse vomeronasal system
2022
Overview
The vomeronasal system plays an essential role in sensing various environmental chemical cues. Here we show that mice exposed to blood and, consequently, hemoglobin results in the activation of vomeronasal sensory neurons expressing a specific vomeronasal G protein-coupled receptor, Vmn2r88, which is mediated by the interaction site, Gly17, on hemoglobin. The hemoglobin signal reaches the medial amygdala (MeA) in both male and female mice. However, it activates the dorsal part of ventromedial hypothalamus (VMHd) only in lactating female mice. As a result, in lactating mothers, hemoglobin enhances digging and rearing behavior. Manipulation of steroidogenic factor 1 (SF1)-expressing neurons in the VMHd is sufficient to induce the hemoglobin-mediated behaviors. Our results suggest that the oxygen-carrier hemoglobin plays a role as a chemosensory signal, eliciting behavioral responses in mice in a state-dependent fashion.
The vomeronasal system regulates sensing of various environmental cues. Here, the authors show that exposure to hemoglobin results in the activation of Vmn2r88+ vomeronasal sensory neurons in both male and female mice. However, exposure to hemoglobin enhances digging and rearing behaviour in lactating female mice only.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 64/60
/ Amygdala
/ Animals
/ Blood
/ Exposure
/ Female
/ Humanities and Social Sciences
/ In Situ Hybridization - methods
/ Male
/ Males
/ Mice
/ Neurons
/ Proto-Oncogene Proteins c-fos - genetics
/ Proto-Oncogene Proteins c-fos - metabolism
/ Receptors, G-Protein-Coupled - genetics
/ Receptors, G-Protein-Coupled - metabolism
/ Rodents
/ Science
/ Sensory Receptor Cells - metabolism
/ Steroidogenic Factor 1 - genetics
/ Steroidogenic Factor 1 - metabolism
/ Ventromedial Hypothalamic Nucleus - metabolism
