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NuA4 and H2A.Z control environmental responses and autotrophic growth in Arabidopsis
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NuA4 and H2A.Z control environmental responses and autotrophic growth in Arabidopsis
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Journal Article
NuA4 and H2A.Z control environmental responses and autotrophic growth in Arabidopsis
2022
Overview
Nucleosomal acetyltransferase of H4 (NuA4) is an essential transcriptional coactivator in eukaryotes, but remains poorly characterized in plants. Here, we describe Arabidopsis homologs of the NuA4 scaffold proteins Enhancer of Polycomb-Like 1 (AtEPL1) and Esa1-Associated Factor 1 (AtEAF1). Loss of AtEAF1 results in inhibition of growth and chloroplast development. These effects are stronger in the
Atepl1
mutant and are further enhanced by loss of Golden2-Like (GLK) transcription factors, suggesting that NuA4 activates nuclear plastid genes alongside GLK. We demonstrate that AtEPL1 is necessary for nucleosomal acetylation of histones H4 and H2A.Z by NuA4 in vitro. These chromatin marks are diminished genome-wide in
Atepl1
, while another active chromatin mark, H3K9 acetylation (H3K9ac), is locally enhanced. Expression of many chloroplast-related genes depends on NuA4, as they are downregulated with loss of H4ac and H2A.Zac. Finally, we demonstrate that NuA4 promotes H2A.Z deposition and by doing so prevents spurious activation of stress response genes.
Function of nucleosomal acetyltransferase of H4 (NuA4), one major complex of HAT, remains unclear in plants. Here, the authors generate mutants targeting two components of the putative NuA4 complex in Arabidopsis (EAF1 and EPL1) and show their roles in photosynthesis genes regulation through H4K5ac and H2A.Z acetylation.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 38/15
/ 38/22
/ 38/23
/ 38/39
/ 38/44
/ 38/77
/ 38/91
/ 45/41
/ 45/44
/ 45/70
/ 82/58
/ 82/80
/ Arabidopsis Proteins - genetics
/ Arabidopsis Proteins - metabolism
/ Autotrophic Processes - genetics
/ Autotrophic Processes - physiology
/ Biology
/ Cloning
/ Gene Expression Regulation, Plant
/ Genes
/ Genomes
/ Histones
/ Homology
/ Humanities and Social Sciences
/ Mutants
/ Mutation
/ Nuclear Pore Complex Proteins - genetics
/ Nuclear Pore Complex Proteins - metabolism
/ Science
