Asset Details
Do you wish to reserve the book?
LNMAT1 promotes lymphatic metastasis of bladder cancer via CCL2 dependent macrophage recruitment
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
LNMAT1 promotes lymphatic metastasis of bladder cancer via CCL2 dependent macrophage recruitment
Do you wish to request the book?
LNMAT1 promotes lymphatic metastasis of bladder cancer via CCL2 dependent macrophage recruitment
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
LNMAT1 promotes lymphatic metastasis of bladder cancer via CCL2 dependent macrophage recruitment
2018
Overview
Tumor-associated macrophages (TAMs) are the most abundant inflammatory infiltrates in the tumor microenvironment and contribute to lymph node (LN) metastasis. However, the precise mechanisms of TAMs-induced LN metastasis remain largely unknown. Herein, we identify a long noncoding RNA, termed Lymph Node Metastasis Associated Transcript 1 (
LNMAT1
), which is upregulated in LN-positive bladder cancer and associated with LN metastasis and prognosis. Through gain and loss of function approaches, we find that
LNMAT1
promotes bladder cancer-associated lymphangiogenesis and lymphatic metastasis. Mechanistically,
LNMAT1
epigenetically activates CCL2 expression by recruiting hnRNPL to CCL2 promoter, which leads to increased H3K4 tri-methylation that ensures hnRNPL binding and enhances transcription. Furthermore,
LNMAT1
-induced upregulation of CCL2 recruits macrophages into the tumor, which promotes lymphatic metastasis via VEGF-C excretion. These findings provide a plausible mechanism for
LNMAT1
-modulated tumor microenvironment in lymphatic metastasis and suggest that
LNMAT1
may represent a potential therapeutic target for clinical intervention in LN-metastatic bladder cancer.
Mechanism of lymph node (LN) metastasis induced by tumor associated macrophages (TAMs) remains unclear. Here they demonstrate that a long noncoding RNA LNMAT1 promotes LN metastasis of bladder cancer via recruitment of TAMs through epigenetic regulation of CCL2 expression.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/109
/ 13/31
/ 13/51
/ 13/89
/ 14/32
/ 38/15
/ 38/22
/ 38/23
/ 38/90
/ 59/5
/ 64/60
/ 82/51
/ 82/58
/ Animals
/ Bladder
/ Cancer
/ Gene Expression Regulation, Neoplastic
/ Humanities and Social Sciences
/ Humans
/ Lymphatic Metastasis - genetics
/ Lymphatic Metastasis - pathology
/ Mice
/ Monocyte chemoattractant protein 1
/ Promoter Regions, Genetic - genetics
/ Ribonucleoproteins - metabolism
/ RNA
/ RNA, Long Noncoding - genetics
/ RNA, Long Noncoding - metabolism
/ Science
/ Tumors
/ Urinary Bladder Neoplasms - genetics
