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Time-restricted feeding restores muscle function in Drosophila models of obesity and circadian-rhythm disruption
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Time-restricted feeding restores muscle function in Drosophila models of obesity and circadian-rhythm disruption
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Journal Article
Time-restricted feeding restores muscle function in Drosophila models of obesity and circadian-rhythm disruption
2019
Overview
Pathological obesity can result from genetic predisposition, obesogenic diet, and circadian rhythm disruption. Obesity compromises function of muscle, which accounts for a majority of body mass. Behavioral intervention that can counteract obesity arising from genetic, diet or circadian disruption and can improve muscle function holds untapped potential to combat the obesity epidemic. Here we show that
Drosophila melanogaster
(fruit fly) subject to obesogenic challenges exhibits metabolic disease phenotypes in skeletal muscle; sarcomere disorganization, mitochondrial deformation, upregulation of Phospho-AKT level, aberrant intramuscular lipid infiltration, and insulin resistance. Imposing time-restricted feeding (TRF) paradigm in which flies were fed for 12 h during the day counteracts obesity-induced dysmetabolism and improves muscle performance by suppressing intramuscular fat deposits, Phospho-AKT level, mitochondrial aberrations, and markers of insulin resistance. Importantly, TRF was effective even in an irregular lighting schedule mimicking shiftwork. Hence, TRF is an effective dietary intervention for combating metabolic dysfunction arising from multiple causes.
Time-restricted feeding (TRF) has beneficial metabolic effects. Here the authors examine how TRF impacts muscle physiology using fly models of metabolically adverse conditions, including diet and genetic models of obesity as well as circadian rhythm disruption, and find that TRF ameliorates skeletal muscle dysfunction.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 14/19
/ 14/28
/ 38
/ 64
/ 64/24
/ 96
/ 96/34
/ 96/63
/ Animals
/ Animals, Genetically Modified
/ Chronobiology Disorders - diet therapy
/ Chronobiology Disorders - etiology
/ Chronobiology Disorders - physiopathology
/ Circadian Rhythm - physiology
/ Diet
/ Diet, High-Fat - adverse effects
/ Energy Metabolism - physiology
/ Feeding
/ Female
/ Humanities and Social Sciences
/ Humans
/ Insects
/ Insulin
/ Lipids
/ Male
/ Metabolic Syndrome - diet therapy
/ Metabolic Syndrome - etiology
/ Metabolic Syndrome - pathology
/ Metabolic Syndrome - physiopathology
/ Mimicry
/ Muscle, Skeletal - pathology
/ Muscle, Skeletal - physiopathology
/ Muscles
/ Obesity
/ Science
