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Kupffer cells prevent pancreatic ductal adenocarcinoma metastasis to the liver in mice
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Kupffer cells prevent pancreatic ductal adenocarcinoma metastasis to the liver in mice
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Journal Article
Kupffer cells prevent pancreatic ductal adenocarcinoma metastasis to the liver in mice
2023
Overview
Although macrophages contribute to cancer cell dissemination, immune evasion, and metastatic outgrowth, they have also been reported to coordinate tumor-specific immune responses. We therefore hypothesized that macrophage polarization could be modulated therapeutically to prevent metastasis. Here, we show that macrophages respond to β-glucan (odetiglucan) treatment by inhibiting liver metastasis. β-glucan activated liver-resident macrophages (Kupffer cells), suppressed cancer cell proliferation, and invoked productive T cell-mediated responses against liver metastasis in pancreatic cancer mouse models. Although excluded from metastatic lesions, Kupffer cells were critical for the anti-metastatic activity of β-glucan, which also required T cells. Furthermore, β-glucan drove T cell activation and macrophage re-polarization in liver metastases in mice and humans and sensitized metastatic lesions to anti-PD1 therapy. These findings demonstrate the significance of macrophage function in metastasis and identify Kupffer cells as a potential therapeutic target against pancreatic cancer metastasis to the liver.
The liver is the most common site of metastasis for pancreatic ductal adenocarcinoma (PDAC). Here, the authors demonstrate that β-glucan, a microbial component associated with trained immunity, activates liver-resident macrophages (Kupffer cells) and prevents PDAC metastasis to the liver
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/51
/ 45/91
/ Animals
/ Cancer
/ Carcinoma, Pancreatic Ductal - drug therapy
/ Carcinoma, Pancreatic Ductal - pathology
/ Glucan
/ Humanities and Social Sciences
/ Humans
/ Lesions
/ Liver
/ Liver Neoplasms - drug therapy
/ Liver Neoplasms - prevention & control
/ Mice
/ Pancreatic Neoplasms - drug therapy
/ Pancreatic Neoplasms - pathology
/ Science
/ β-Glucan
