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Effects of Aurora kinase A on mouse decidualization via Stat3-plk1-cdk1 pathway
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Effects of Aurora kinase A on mouse decidualization via Stat3-plk1-cdk1 pathway
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Effects of Aurora kinase A on mouse decidualization via Stat3-plk1-cdk1 pathway
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Journal Article
Effects of Aurora kinase A on mouse decidualization via Stat3-plk1-cdk1 pathway
2021
Overview
Background
Decidualization is essential to the successful pregnancy in mice. The molecular mechanisms and effects of Aurora kinase A (Aurora A) remain poorly understood during pregnancy. This study is the first to investigate the expression and role of Aurora A during mouse decidualization.
Methods
Quantitative real time polymerase chain reaction, western blotting and in situ hybridization were used to determine the expression of Aurora A in mouse uteri. Aurora A activity was inhibited by Aurora A inhibitor to explore the role of Aurora A on decidualization via regulating the Aurora A/Stat3/Plk1/Cdk1 signaling pathway.
Results
Aurora A was strongly expressed at implantation sites compared with inter-implantation sites. Furthermore, Aurora A was also significantly increased in oil-induced deciduoma compared with control. Both Aurora A mRNA and protein were significantly increased under in vitro decidualization. Under in vitro decidualization, Prl8a2, a marker of mouse decidualization, was significantly decreased by TC-S 7010, an Aurora A inhibitor. Additionally, Prl8a2 was reduced by Stat3 inhibitor, Plk1 inhibitor and Cdk1 inhibitor, respectively. Moreover, the protein levels of p-Stat3, p-Plk1 and p-Cdk1 were suppressed by TC-S 7010. The protein levels of p-Stat3, p-Plk1 and p-Cdk1 were also suppressed by S3I-201, a Stat3 inhibitor). SBE 13 HCl (Plk1 inhibitor) could reduce the protein levels of p-Plk1 and p-Cdk1. Collectively, Aurora A could regulate Stat3/Plk1/Cdk1 signaling pathway.
Conclusion
Our study shows that Aurora A is expressed in decidual cells and should be important for mouse decidualization. Aurora A/Stat3/Plk1/Cdk1 signaling pathway may be involved in mouse decidualization.
Publisher
BioMed Central,BioMed Central Ltd,BMC
Subject
/ Aurora A
/ Aurora Kinase A - antagonists & inhibitors
/ Aurora Kinase A - biosynthesis
/ CDC2 Protein Kinase - antagonists & inhibitors
/ CDC2 Protein Kinase - metabolism
/ Cdk1
/ Cell Cycle Proteins - antagonists & inhibitors
/ Cell Cycle Proteins - metabolism
/ Decidua
/ Embryos
/ Enzyme Inhibitors - pharmacology
/ Female
/ Kinases
/ Medicine
/ Mice
/ mRNA
/ Plk1
/ Protein Serine-Threonine Kinases - antagonists & inhibitors
/ Protein Serine-Threonine Kinases - metabolism
/ Proteins
/ Proto-Oncogene Proteins - antagonists & inhibitors
/ Proto-Oncogene Proteins - metabolism
/ Signal Transduction - drug effects
/ Signal Transduction - physiology
/ Stat3
/ STAT3 Transcription Factor - antagonists & inhibitors
/ STAT3 Transcription Factor - metabolism
/ Uterus
