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Deletion of ESX-3 and ESX-4 secretion systems in Mycobacterium abscessus results in highly impaired pathogenicity
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Deletion of ESX-3 and ESX-4 secretion systems in Mycobacterium abscessus results in highly impaired pathogenicity
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Journal Article
Deletion of ESX-3 and ESX-4 secretion systems in Mycobacterium abscessus results in highly impaired pathogenicity
2025
Overview
Type VII secretion systems participate in protein export, virulence, conjugation, and metabolic regulation. Five subtypes (ESX-1 to ESX-5) exist, each with specific roles and well-characterized secretion profiles in various mycobacterial species.
Mycobacterium abscessus
, encodes only ESX-3 and ESX-4. Here, single and double
M. abscessus
mutants lacking the main ATPases EccC3 and EccC4 were used to define ESX-3 and ESX-4 contributions to substrate secretion and virulence. Our results demonstrate that EsxG/H secretion depends entirely on ESX-3, whereas both ESX-3 and ESX-4 secrete EsxU/T. Furthermore, two newly identified PE/PPE substrates (MAB_0046/MAB_0047) require ESX-3 for secretion. Functional complementation restored secretion and revealed subpolar localization of these systems. Macrophage infections showed that ESX-3 and ESX-4 contribute to bacterial internalization, phagosomal escape, and intracellular survival. In mice, infections with
eccC3-
and/or
eccC4
-deletion mutants resulted in complete survival and reduced bacterial loads in the lungs. These findings demonstrate that both ESX systems drive
M. abscessus
pathogenicity.
Investigation of ESX-3 and ESX-4 secretion systems in
Mycobacterium abscessus
reveals their crucial role in substrate secretion, macrophage infection, and in vivo pathogenicity, highlighting their role in mycobacterial survival and host interactions.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
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/ 96
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/ Animals
/ Bacterial Proteins - genetics
/ Bacterial Proteins - metabolism
/ Biofilms
/ Biomedical and Life Sciences
/ Female
/ Mice
/ Mutants
/ Mycobacterium abscessus - genetics
/ Mycobacterium abscessus - metabolism
/ Mycobacterium abscessus - pathogenicity
/ Mycobacterium Infections, Nontuberculous - microbiology
/ Roles
/ Type VII Secretion Systems - genetics
