Asset Details
Do you wish to reserve the book?
Performance of lymph node cytopathology in diagnosis and characterization of lymphoma in dogs
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Performance of lymph node cytopathology in diagnosis and characterization of lymphoma in dogs
Do you wish to request the book?
Performance of lymph node cytopathology in diagnosis and characterization of lymphoma in dogs
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Performance of lymph node cytopathology in diagnosis and characterization of lymphoma in dogs
2022
Overview
Abstract
Background
Cytopathology is a minimally invasive and convenient diagnostic procedure, often used as a substitute for histopathology to diagnose and characterize lymphoma in dogs.
Objectives
Assess the diagnostic performance of cytopathology in diagnosing lymphoma and its histopathological subtypes in dogs.
Animals
One-hundred and sixty-one lymph node samples from 139 dogs with enlarged peripheral lymph nodes.
Methods
Based only on cytopathology, 6 examiners independently provided the following interpretations on each sample: (a) lymphoma vs nonlymphoma; (b) grade and phenotype; and (c) World Health Organization (WHO) histopathological subtype. Histopathology and immunohistochemistry (IHC) findings were used as reference standards to evaluate diagnostic performance of cytopathology. Clinical, clinicopathologic, and imaging data also were considered in the definitive diagnosis.
Results
Classification accuracy for lymphoma consistently was >80% for all examiners, whereas it was >60% for low grade T-cell lymphomas, >30% for high grade B-cell lymphomas, >20% for high grade T-cell lymphomas, and <40% for low grade B-cell lymphomas. Interobserver agreement evaluated by kappa scores was 0.55 and 0.32 for identification of lymphoma cases, and of grade plus immunophenotype, respectively.
Conclusions and Clinical Importance
Cytopathology may result in accurate diagnosis of lymphoma, but accuracy decreases when further characterization is needed. Cytopathology represents a fundamental aid in identifying lymphoma and can be used as a screening test to predict grade and phenotype. However, these results must be confirmed using other ancillary techniques, including flow cytometry, histopathology, and immunohistochemistry (IHC).
Publisher
Oxford University Press,John Wiley & Sons, Inc,Wiley
Subject
