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Routing of the RAB6 secretory pathway towards the lysosome related organelle of melanocytes
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Routing of the RAB6 secretory pathway towards the lysosome related organelle of melanocytes
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Journal Article
Routing of the RAB6 secretory pathway towards the lysosome related organelle of melanocytes
2017
Overview
Exocytic carriers convey neo-synthesized components from the Golgi apparatus to the cell surface. While the release and anterograde movement of Golgi-derived vesicles require the small GTPase RAB6, its effector ELKS promotes the targeting and docking of secretory vesicles to particular areas of the plasma membrane. Here, we show that specialized cell types exploit and divert the secretory pathway towards lysosome related organelles. In cultured melanocytes, the secretory route relies on RAB6 and ELKS to directly transport and dock Golgi-derived carriers to melanosomes. By delivering specific cargos, such as MART-1 and TYRP2/ DCT, the RAB6/ELKS-dependent secretory pathway controls the formation and maturation of melanosomes but also pigment synthesis. In addition, pigmentation defects are observed in RAB6 KO mice. Our data together reveal for the first time that the secretory pathway can be directed towards intracellular organelles of endosomal origin to ensure their biogenesis and function.
The anterograde movement of Golgi-derived vesicles requires the small GTPase RAB6, while its effector ELKS targets these vesicles to particular areas of the plasma membrane. Here the authors show that RAB6 and ELKS function in the biogenesis of melanosome, demonstrating that the secretory pathway can be directed towards intracellular organelles of endosomal origin.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 14/19
/ 14/28
/ 14/35
/ 14/63
/ 38/109
/ 38/88
/ 64/110
/ 64/60
/ Animals
/ Carrier Proteins - metabolism
/ Defects
/ Docking
/ Female
/ Genes
/ Golgi Apparatus - metabolism
/ Humanities and Social Sciences
/ Male
/ Mice
/ Nerve Tissue Proteins - genetics
/ Nerve Tissue Proteins - metabolism
/ rab GTP-Binding Proteins - genetics
/ rab GTP-Binding Proteins - metabolism
/ Rodents
/ Science
/ Vesicles
