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Interleukin 4 is important in protective immunity to a gastrointestinal nematode infection in mice
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Interleukin 4 is important in protective immunity to a gastrointestinal nematode infection in mice
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Interleukin 4 is important in protective immunity to a gastrointestinal nematode infection in mice
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Journal Article
Interleukin 4 is important in protective immunity to a gastrointestinal nematode infection in mice
1991
Overview
Parasitic helminths typically induce components of immediate-type hypersensitivity, including elevated serum IgE, eosinophilia, and mucosal mast cells. These responses are T-cell-dependent and associated with rapid expulsion of parasitic worms from a sensitized host; existing experimental systems have failed to define the precise role of cytokines in these responses. We report here that anti-interleukin 4 or anti-interleukin 4 receptor antibodies block the polyclonal IgE response to a parasitic nematode, Heligmosomoides polygyrus, and abrogate protective immunity to the infection. In contrast, anti-interleukin 5 antibody prevented H. polygyrus-induced eosinophilia but did not prevent protection. These data provide evidence that a specific cytokine affects the physiology and survival of a parasitic nematode in the host.
Publisher
National Academy of Sciences of the United States of America
Subject
/ Antibodies, Helminth - biosynthesis
/ Antibodies, Monoclonal - immunology
/ Biological and medical sciences
/ Female
/ Fundamental and applied biological sciences. Psychology
/ Gastrointestinal Diseases - immunology
/ Gastrointestinal Diseases - parasitology
/ Heligmosomatoidea - immunology
/ Immediate hypersensitivity. Allergy. Anaphylaxis, etc
/ IMMUNITE
/ Immunity
/ Immunoglobulin E - biosynthesis
/ Mice
/ Nematode Infections - immunology
/ RATON
/ Reaction mechanisms, antibodies, chemical mediators
/ Receptors, Mitogen - physiology
/ SOURIS
/ SURVIE
/ Worms
