Asset Details
Do you wish to reserve the book?
Recombinant West Nile virus envelope protein E and domain III expressed in insect larvae protects mice against West Nile disease
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Recombinant West Nile virus envelope protein E and domain III expressed in insect larvae protects mice against West Nile disease
Do you wish to request the book?
Recombinant West Nile virus envelope protein E and domain III expressed in insect larvae protects mice against West Nile disease
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Recombinant West Nile virus envelope protein E and domain III expressed in insect larvae protects mice against West Nile disease
2011
Overview
In this study, West Nile virus (WNV) envelope (rE) protein and its domain III (rDIII) were efficiently expressed in a cost-effective system based on insect larvae as non-fermentative living biofactories. Mice immunized with the partially purified rE or rDIII elicited high antibodies titers that neutralized viral infectivity in cell culture and in suckling mice. All vaccinated animals were fully protected when challenged with neurovirulent WNV NY99. Passive transfer of protective antibodies from immunized mothers to their offspring occurred both by transplacental and lactation routes. These results indicate that the insect-derived antigens tested may constitute potential vaccine candidates to be further evaluated.
Publisher
Elsevier Ltd,Elsevier,Elsevier Limited
Subject
/ Animals
/ antigens
/ Biological and medical sciences
/ Female
/ Fundamental and applied biological sciences. Psychology
/ Gene Expression Regulation, Viral
/ Insects
/ Larvae
/ Mice
/ mothers
/ progeny
/ Protein Structure, Tertiary - genetics
/ suckling
/ Vaccine
/ Vaccines
/ Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
/ Vaccines, Synthetic - administration & dosage
/ Vaccines, Synthetic - biosynthesis
/ Vaccines, Synthetic - immunology
/ Viral Envelope Proteins - biosynthesis
/ Viral Envelope Proteins - genetics
/ Viral Envelope Proteins - immunology
/ Virology
/ West Nile Fever - immunology
/ West Nile Fever - prevention & control
/ West Nile virus - immunology
/ West Nile virus - pathogenicity
