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Clinical update: treating osteoarthritis
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Journal Article
Clinical update: treating osteoarthritis
2007
Overview
Several industry-sponsored trials have shown benefit with glucosamine for pain and function in osteoarthritis, and a Cochrane review concluded that at least one of the available preparations was effective.13 However, a subsequent large pivotal trial funded by the US National Institutes of Health showed that after 24 weeks of treatment neither glucosamine or chondroitin sulfate, nor a combination of the two, was more efficacious than was placebo for treatment of osteoarthritic knee pain.14 The side-effects of glucosamine and chondroitin sulfate were similar to those of placebo. Some evidence suggests that braces, insoles, and assistive devices decrease osteoarthritic pain and improve function.2-6,18 Weight loss results in decreased pain and improved function in overweight or obese patients with osteoarthritis of the knee.19 Because exercise combined with diet results in a greater weight reduction than does diet alone, both components should be included in self-management programmes.
Publisher
Elsevier Ltd,Elsevier Limited
Subject
/ Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
/ Arthroplasty, Replacement, Knee
/ Cyclooxygenase Inhibitors - therapeutic use
/ Disease
/ Drugs
/ Female
/ Humans
/ Male
/ Ortopedi
/ Osteoarthritis - classification
/ Osteoarthritis - drug therapy
/ Osteoarthritis - physiopathology
/ Pain
/ Patients
/ Sulfates
