Asset Details
Do you wish to reserve the book?
NMR metabolomics of cerebrospinal fluid differentiates inflammatory diseases of the central nervous system
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
NMR metabolomics of cerebrospinal fluid differentiates inflammatory diseases of the central nervous system
Do you wish to request the book?
NMR metabolomics of cerebrospinal fluid differentiates inflammatory diseases of the central nervous system
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
NMR metabolomics of cerebrospinal fluid differentiates inflammatory diseases of the central nervous system
2018
Overview
Myriad infectious and noninfectious causes of encephalomyelitis (EM) have similar clinical manifestations, presenting serious challenges to diagnosis and treatment. Metabolomics of cerebrospinal fluid (CSF) was explored as a method of differentiating among neurological diseases causing EM using a single CSF sample.
1H NMR metabolomics was applied to CSF samples from 27 patients with a laboratory-confirmed disease, including Lyme disease or West Nile Virus meningoencephalitis, multiple sclerosis, rabies, or Histoplasma meningitis, and 25 controls. Cluster analyses distinguished samples by infection status and moderately by pathogen, with shared and differentiating metabolite patterns observed among diseases. CART analysis predicted infection status with 100% sensitivity and 93% specificity.
These preliminary results suggest the potential utility of CSF metabolomics as a rapid screening test to enhance diagnostic accuracies and improve patient outcomes.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Central Nervous System - immunology
/ Central Nervous System Diseases - cerebrospinal fluid
/ Central Nervous System Diseases - diagnosis
/ Central Nervous System Diseases - immunology
/ Cerebrospinal Fluid - chemistry
/ Child
/ Diseases
/ Female
/ Humans
/ Magnetic Resonance Spectroscopy - methods
/ Male
/ Medicine
/ Medicine and Health Sciences
/ NMR
/ Nuclear magnetic resonance spectroscopy
/ Patients
/ Rabies
/ Samples
/ Viruses
