Asset Details
Do you wish to reserve the book?
Operant Behavioral Responses to Orofacial Cold Stimuli in Rats with Chronic Constrictive Trigeminal Nerve Injury: Effects of Menthol and Capsazepine
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Operant Behavioral Responses to Orofacial Cold Stimuli in Rats with Chronic Constrictive Trigeminal Nerve Injury: Effects of Menthol and Capsazepine
Do you wish to request the book?
Operant Behavioral Responses to Orofacial Cold Stimuli in Rats with Chronic Constrictive Trigeminal Nerve Injury: Effects of Menthol and Capsazepine
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Operant Behavioral Responses to Orofacial Cold Stimuli in Rats with Chronic Constrictive Trigeminal Nerve Injury: Effects of Menthol and Capsazepine
2013
Overview
Both spinal and trigeminal somatosensory systems use the TRPM8 channel as a principal transducer for detecting cold stimuli. It is currently unclear whether this cold transducer may play a role in trigeminal neuropathic pain manifesting cold allodynia and hyperalgesia. In the present study, trigeminal neuropathy was induced by chronic constrictive nerve injury of the infraorbital nerve (ION-CCI). Behavioral responses to cold stimuli in orofacial regions were assessed by the newly developed orofacial operant test in the ION-CCI rats. We tested menthol and capsazepine, two compounds that can activate and inhibit TRPM8 respectively, on orofacial operant responses to cold stimuli in ION-CCI rats. Testing animals performed operant tasks by voluntarily contacting their orofacial regions to a cold stimulation module in order to access sweetened milk as a reward, and contact time and number of the operant behaviors were automatically recorded. Total contact time was significantly reduced at the cooling temperatures of 17°C and 12°C in ION-CCI group in comparison with sham group, indicating the presence of cold allodynia and hyperalgesia in ION-CCI rats. When menthol was administered to ION-CCI rats, total contact time was further reduced and total contact number increased at the cooling temperatures. In contrast, after administration of capsazepine to ION-CCI rats, total contact time was significantly increased at the cooling temperatures. The behavioral outcomes support the idea that TRPM8 plays a role in cold allodynia and hyperalgesia following chronic trigeminal nerve injury.
Publisher
SAGE Publications,BioMed Central,BioMed Central Ltd,Sage Publications Ltd
Subject
/ Animals
/ Behavior
/ Behavior, Animal - drug effects
/ Behavior, Animal - physiology
/ Capsaicin - analogs & derivatives
/ Cold
/ Complications and side effects
/ Conditioning, Operant - drug effects
/ Conditioning, Operant - physiology
/ Cooling
/ Male
/ Medicine
/ Milk
/ Pain
/ Rats
/ Rodents
/ Software
/ Trigeminal Nerve - drug effects
/ Trigeminal Nerve - pathology
/ Trigeminal Nerve Injuries - metabolism
