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Environmental pH and peptide signaling control virulence of Streptococcus pyogenes via a quorum-sensing pathway
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Environmental pH and peptide signaling control virulence of Streptococcus pyogenes via a quorum-sensing pathway
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Journal Article
Environmental pH and peptide signaling control virulence of Streptococcus pyogenes via a quorum-sensing pathway
2019
Overview
Bacteria control gene expression in concert with their population density by a process called quorum sensing, which is modulated by bacterial chemical signals and environmental factors. In the human pathogen
Streptococcus pyogenes
, production of secreted virulence factor SpeB is controlled by a quorum-sensing pathway and environmental pH. The quorum-sensing pathway consists of a secreted leaderless peptide signal (SIP), and its cognate receptor RopB. Here, we report that the SIP quorum-sensing pathway has a pH-sensing mechanism operative through a pH-sensitive histidine switch located at the base of the SIP-binding pocket of RopB. Environmental acidification induces protonation of His144 and reorganization of hydrogen bonding networks in RopB, which facilitates SIP recognition. The convergence of two disparate signals in the SIP signaling pathway results in induction of SpeB production and increased bacterial virulence. Our findings provide a model for investigating analogous crosstalk in other microorganisms.
The mechanism by which environmental pH controls the virulence of the pathogen
Streptococcus pyogenes
is unclear. Here, Do et al. show that changes in pH affect the activity of the virulence regulator RopB via its interaction with a quorum-sensing peptide signal.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 38/70
/ 38/90
/ 82/80
/ 82/83
/ 96
/ Animals
/ Bacteria
/ Bacterial Proteins - metabolism
/ Female
/ Gene Expression Regulation, Bacterial - physiology
/ Humanities and Social Sciences
/ Humans
/ Mice
/ Peptides
/ Protein Sorting Signals - physiology
/ Science
/ Science & Technology - Other Topics
/ Signal Transduction - physiology
/ Streptococcal Infections - microbiology
/ Streptococcal Infections - mortality
/ Streptococcus pyogenes - pathogenicity
