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Bioengineered bacteria-derived outer membrane vesicles as a versatile antigen display platform for tumor vaccination via Plug-and-Display technology
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Bioengineered bacteria-derived outer membrane vesicles as a versatile antigen display platform for tumor vaccination via Plug-and-Display technology
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Journal Article
Bioengineered bacteria-derived outer membrane vesicles as a versatile antigen display platform for tumor vaccination via Plug-and-Display technology
2021
Overview
An effective tumor vaccine vector that can rapidly display neoantigens is urgently needed. Outer membrane vesicles (OMVs) can strongly activate the innate immune system and are qualified as immunoadjuvants. Here, we describe a versatile OMV-based vaccine platform to elicit a specific anti-tumor immune response via specifically presenting antigens onto OMV surface. We first display tumor antigens on the OMVs surface by fusing with ClyA protein, and then simplify the antigen display process by employing a Plug-and-Display system comprising the tag/catcher protein pairs. OMVs decorated with different protein catchers can simultaneously display multiple, distinct tumor antigens to elicit a synergistic antitumour immune response. In addition, the bioengineered OMVs loaded with different tumor antigens can abrogate lung melanoma metastasis and inhibit subcutaneous colorectal cancer growth. The ability of the bioengineered OMV-based platform to rapidly and simultaneously display antigens may facilitate the development of these agents for personalized tumour vaccines.
Outer membrane vesicles (OMVs), non-replicative particles secreted by Gram-negative bacteria, are known for their immunostimulatory and adjuvant properties. Here, by employing a Plug-and-Display technology, the authors engineer OMVs to display tumor antigens on the surface, a platform that promotes anti-tumor immune responses in preclinical cancer models.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 147/143
/ 59/5
/ 64
/ 64/60
/ 82/51
/ 82/80
/ 96
/ 96/31
/ Animals
/ Antigen Presentation - immunology
/ Antigens
/ Antigens, Bacterial - metabolism
/ Antigens, Neoplasm - metabolism
/ Bacteria
/ Bacterial Outer Membrane Proteins - metabolism
/ Cancer
/ Cancer Vaccines - immunology
/ Catchers
/ Dendritic Cells - metabolism
/ Extracellular Vesicles - metabolism
/ Female
/ Humanities and Social Sciences
/ Melanoma
/ Mice
/ Plugs
/ Proteins
/ Science
/ Tumors
/ Vaccines
/ Vesicles
