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Efficacy and safety of duloxetine in chronic musculoskeletal pain: a systematic review and meta-analysis
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Efficacy and safety of duloxetine in chronic musculoskeletal pain: a systematic review and meta-analysis
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Efficacy and safety of duloxetine in chronic musculoskeletal pain: a systematic review and meta-analysis
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Journal Article
Efficacy and safety of duloxetine in chronic musculoskeletal pain: a systematic review and meta-analysis
2023
Overview
Background
Chronic musculoskeletal pain (CMP) is a complex condition that is mainly treated with analgesic drugs. However, antidepressant intervention is also an important factor in the treatment of CMP. Duloxetine is an effective treatment option for patients with CMP as its antidepressant effect. The purpose of this article is to evaluate the efficacy and safety of duloxetine in treating CMP.
Databases and data treatment
We searched PubMed, Web of Science, Embase, Cochrane Library from inception to May, 2022. Randomized controlled trials (RCTs) evaluating the efficacy and safety of duloxetine versus placebo in patients with CMP were included. We identified 13 articles and studied a population of 4201 participants in 4 countries.
Results
This meta-analysis showed that the duloxetine has statistically significant compared with the placebo control, benefits on 24-hour average pain, living quality, physical function, and global impressions and there was no difference in the incidence of serious adverse event. In general, duloxetine can improve mood and pain level at the same time.
Conclusions
This review shows a significant contribution of duloxetine to CMP symptom relief. This meta-analysis improved that duloxetine can significantly reduce the pain level of patients, improve depressive symptoms and global impression, and has no obvious serious adverse reactions. However, additional studies are required to confirm the relationship between psychological diseases and chronic pain and explore their internal links.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
