Journal Article

Predictive value of preoperative CT enhancement rate and CT perfusion parameters in colorectal cancer

Li, Ze-mao, Zhou, Wei, Zhang, Hui-ying, Feng, Li, Chen, Wei-bin

2024

Overview

Background Angiogenesis is a critical step in colorectal cancer growth, progression and metastasization. CT are routine imaging examinations for preoperative clinical evaluation in colorectal cancer patients. This study aimed to investigate the predictive value of preoperative CT enhancement rate (CER) and CT perfusion parameters on angiogenesis in colorectal cancer, as well as the association of preoperative CER and CT perfusion parameters with serum markers. Methods This retrospective analysis included 42 patients with colorectal adenocarcinoma. Median of microvessel density (MVD) as the cut-off value, it divided 42 patients into high-density group (MVD ≥ 35/field, n  = 24) and low-density group (MVD < 35/field, n  = 18), and 25 patients with benign colorectal lesions were collected as the control group. Statistical analysis of CER, CT perfusion parameters, serum markers were performed in all groups. Receiver operating curves (ROC) were plotted to evaluate the diagnostic efficacy of relevant CT perfusion parameters for tumor angiogenesis; Pearson correlation analysis explored potential association between CER, CT perfusion parameters and serum markers. Results CER, blood volume (BV), blood flow (BF), permeability surface (PS) and carbohydrate antigen 19 − 9 (CA19-9), carbohydrate antigen 125 (CA125), carcinoembryonic antigen (CEA), trefoil factor 3 (TFF3), vascular endothelial growth factor (VEGF) in colorectal adenocarcinoma were significantly higher than those in the control group, the parameters in high-density group were significantly higher than those in the low-density group ( P  < 0.05); however, the time to peak (TTP) of patients in colorectal adenocarcinoma were significantly lower than those in the control group, and the high-density group showed a significantly lower level compared to the low-density group ( P  < 0.05). The combined parameters BF + TTP + PS and BV + BF + TTP + PS demonstrated the highest area under the curve (AUC), both at 0.991. Pearson correlation analysis showed that the serum levels of CA19-9, CA125, CEA, TFF3, and VEGF in patients showed positive correlations with CER, BV, BF, and PS ( P  < 0.05), while these indicators exhibited negative correlations with TTP ( P  < 0.05). Conclusions Some single and joint preoperative CT perfusion parameters can accurately predict tumor angiogenesis in colorectal adenocarcinoma. Preoperative CER and CT perfusion parameters have certain association with serum markers.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Adenocarcinoma / Adenocarcinoma - blood / Adenocarcinoma - blood supply / Adenocarcinoma - diagnostic imaging / Adenocarcinoma - pathology / Adult / Aged / Analysis / Angiogenesis / Antigens / Biomarkers / Biomarkers, Tumor - blood / Blood flow / Blood vessels / Blood Volume / CA-19-9 Antigen - blood / Carcinoembryonic antigen / Carcinoembryonic Antigen - blood / Care and treatment / CEA (Oncology) / Colorectal cancer / Colorectal carcinoma / Colorectal Neoplasms - blood / Colorectal Neoplasms - blood supply / Colorectal Neoplasms - diagnostic imaging / Colorectal Neoplasms - pathology / Computed tomography / Correlation analysis / CT imaging / CT perfusion imaging / Data analysis / Development and progression / Diagnosis / Enzymes / Female / Females / Gastroenterology / Hepatology / Humans / Indicator organisms / Internal Medicine / Iodine / Male / Medical imaging / Medical research / Medicine / Medicine & Public Health / Medicine, Experimental / Metastasis / Microvascular Density / Middle Aged / Neovascularization / Neovascularization, Pathologic - blood / Neovascularization, Pathologic - diagnostic imaging / Patient outcomes / Patients / Perfusion / Permeability / Predictive Value of Tests / Preoperative Care - methods / Regression analysis / Retrospective Studies / ROC Curve / Serum levels / Sialyl Lewis a antigen / Software / Statistical analysis / Testing / Tomography, X-Ray Computed - methods / Trefoil factor / Tumor angiogenesis / Tumor markers / Tumors / Vascular endothelial growth factor / Vascular Endothelial Growth Factor A - blood