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Novel variants underlying autosomal recessive intellectual disability in Pakistani consanguineous families
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Novel variants underlying autosomal recessive intellectual disability in Pakistani consanguineous families
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Journal Article
Novel variants underlying autosomal recessive intellectual disability in Pakistani consanguineous families
2020
Overview
Background
Intellectual disability (ID) is both a clinically diverse and genetically heterogeneous group of disorder, with an onset of cognitive impairment before the age of 18 years. ID is characterized by significant limitations in intellectual functioning and adaptive behaviour. The identification of genetic variants causing ID and neurodevelopmental disorders using whole-exome sequencing (WES) has proven to be successful. So far more than 1222 primary and 1127 candidate genes are associated with ID.
Methods
To determine pathogenic variants causative of ID in three unrelated consanguineous Pakistani families, we used a combination of WES, homozygosity-by-descent mapping, de-deoxy sequencing and bioinformatics analysis.
Results
Rare pathogenic single nucleotide variants identified by WES which passed our filtering strategy were confirmed by traditional Sanger sequencing and segregation analysis. Novel and deleterious variants in
VPS53
,
GLB1
, and
MLC1
, genes previously associated with variable neurodevelopmental anomalies, were found to segregate with the disease in the three families.
Conclusions
This study expands our knowledge on the molecular basis of ID as well as the clinical heterogeneity associated to different rare genetic causes of neurodevelopmental disorders. This genetic study could also provide additional knowledge to help genetic assessment as well as clinical and social management of ID in Pakistani families.
Publisher
BioMed Central,BioMed Central Ltd,BMC
Subject
/ beta-Galactosidase - genetics
/ Biomedical and Life Sciences
/ Child
/ Diseases
/ Family
/ Female
/ Genes
/ Genetic epidemiology and genetic associations
/ Genomes
/ Humans
/ Intellectual Disability - complications
/ Intellectual Disability - genetics
/ Intellectual Disability - pathology
/ Male
/ Membrane Proteins - genetics
/ Neurodevelopmental disorders
/ Neurodevelopmental Disorders - complications
/ Neurodevelopmental Disorders - genetics
/ Neurodevelopmental Disorders - pathology
/ Novels
/ Patients
/ Pedigree
/ Studies
