Journal Article

Evidence-based complementary and alternative medicine conventional surgery combined with traditional Chinese medicinal retention enema for tubal obstructive infertility: A systematic review and meta-analysis

Jin, Shuo, Zhang, Qin, Xu, Sijia, Yang, Liuqing, Wang, Ling

2023

Overview

Chinese medicinal retention enemas have gradually attracted the attention of clinicians as an alternative approach for tubal obstructive infertility. The purpose of this study was to investigate the efficacy and safety of conventional surgery combined with traditional Chinese medicinal retention enemas for the treatment of tubal obstructive infertility. Eight electronic databases were searched from their inception to November 30, 2022. To assess the efficacy and safety of different treatments, following outcomes were measured: clinical pregnancy rate, clinical total effective rate, incidence of ectopic pregnancy, the improvement of Traditional Chinese Medicinal (TCM) symptoms, the improvement of the signs of obstructive tubal infertility and side effects. A total of 23 Randomized Controlled Trials (RCTs) with 1909 patients met the inclusion criteria. The pooled results showed a higher pregnancy rate in the experimental group than in the control group (RR 1.75, 95% CI [1.58, 1.94], Z = 10.55, P<0.00001). The clinical total effective rate in the experimental group was higher than that in the control group (RR 1.28, 95% CI [1.23, 1.34], Z = 11.07, P<0.00001). The incidence of ectopic pregnancy in the experimental group was lower than that in the control group (RR 0.40, 95% CI [0.20, 0.77], Z = -2.73, P = 0.01). Based on current evidence, we concluded that conventional surgery combined with traditional Chinese medicinal retention enema for tubal obstructive infertility was superior to conventional surgery alone in improving the clinical pregnancy rate, improving clinical total effective rate, improving TCM symptoms, improving the signs of obstructive tubal infertility and lowering the incidence of ectopic pregnancy. However, further clinical trials with high-quality methodologies need to be conducted.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Acupuncture / Alternative medicine / Analysis / Bias / Care and treatment / Chinese medicine / Clinical trials / Complementary Therapies / Complications and side effects / Drugs, Chinese Herbal - therapeutic use / Ectopic pregnancy / Effectiveness / Endometriosis / Endoscopy / Enema / Evidence-based medicine / Fallopian tubes / Female / Gynecology / Handbooks / Health risks / Humans / Infertility / Infertility - drug therapy / Intervention / Laparoscopy / Medicine and Health Sciences / Medicine, Chinese / Medicine, Chinese Traditional / Meta-analysis / Patient outcomes / Physical Sciences / Pregnancy / Pregnancy complications / Pregnancy, Ectopic - drug therapy / Research and Analysis Methods / Retention / Safety / Side effects / Software / Surgery / Systematic review / Traditional Chinese medicine