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Control of sexual differentiation and behavior by the doublesex gene in Drosophila melanogaster
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Control of sexual differentiation and behavior by the doublesex gene in Drosophila melanogaster
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Journal Article
Control of sexual differentiation and behavior by the doublesex gene in Drosophila melanogaster
2010
Overview
This study defines the roles of the
doublesex
gene in male and female flies' courtship circuitry and behaviors.
Doublesex proteins, which are part of the structurally and functionally conserved
Dmrt
gene family, are important for sex determination throughout the animal kingdom. We inserted
Gal4
into the
doublesex
(
dsx
) locus of
Drosophila melanogaster
, allowing us to visualize and manipulate cells expressing
dsx
in various tissues. In the nervous system, we detected differences between the sexes in
dsx
-positive neuronal numbers, axonal projections and synaptic density. We found that
dsx
was required for the development of male-specific neurons that coexpressed
fruitless
(
fru
), a regulator of male sexual behavior. We propose that
dsx
and
fru
act together to form the neuronal framework necessary for male sexual behavior. We found that disrupting
dsx
neuronal function had profound effects on male sexual behavior. Furthermore, our results suggest that
dsx
-positive neurons are involved in pre- to post-copulatory female reproductive behaviors.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Animal Genetics and Genomics
/ Animals
/ Biomedical and Life Sciences
/ DNA-Binding Proteins - biosynthesis
/ DNA-Binding Proteins - deficiency
/ DNA-Binding Proteins - genetics
/ DNA-Binding Proteins - physiology
/ Drosophila melanogaster - genetics
/ Drosophila melanogaster - physiology
/ Drosophila Proteins - biosynthesis
/ Drosophila Proteins - deficiency
/ Drosophila Proteins - genetics
/ Drosophila Proteins - physiology
/ Female
/ Male
