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Experimental infection of cattle with Mycobacterium tuberculosis isolates shows the attenuation of the human tubercle bacillus for cattle
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Experimental infection of cattle with Mycobacterium tuberculosis isolates shows the attenuation of the human tubercle bacillus for cattle
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Journal Article
Experimental infection of cattle with Mycobacterium tuberculosis isolates shows the attenuation of the human tubercle bacillus for cattle
2018
Overview
The
Mycobacterium tuberculosis
complex (MTBC) is the collective term given to the group of bacteria that cause tuberculosis (TB) in mammals. It has been reported that
M. tuberculosis
H37Rv, a standard reference MTBC strain, is attenuated in cattle compared to
Mycobacterium bovis
. However, as
M. tuberculosis
H37Rv was isolated in the early 1930s, and genetic variants are known to exist, we sought to revisit this question of attenuation of
M. tuberculosis
for cattle by performing a bovine experimental infection with a recent
M. tuberculosis
isolate. Here we report infection of cattle using
M. bovis
AF2122/97,
M. tuberculosis
H37Rv, and
M. tuberculosis
BTB1558, the latter isolated in 2008 during a TB surveillance project in Ethiopian cattle. We show that both
M. tuberculosis
strains caused reduced gross pathology and histopathology in cattle compared to
M. bovis
. Using
M. tuberculosis
H37Rv and
M. bovis
AF2122/97 as the extremes in terms of infection outcome, we used RNA-Seq analysis to explore differences in the peripheral response to infection as a route to identify biomarkers of progressive disease in contrast to a more quiescent, latent infection. Our work shows the attenuation of
M. tuberculosis
strains for cattle, and emphasizes the potential of the bovine model as a ‘One Health’ approach to inform human TB biomarker development and post-exposure vaccine development.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 38/39
/ 38/91
/ Animals
/ Bovidae
/ Cattle
/ Female
/ Humanities and Social Sciences
/ Humans
/ Microbiology and Parasitology
/ Mycobacterium bovis - immunology
/ Mycobacterium tuberculosis - immunology
/ RNA
/ Science
/ Tuberculosis, Bovine - immunology
/ Tuberculosis, Bovine - metabolism
