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Learned spatiotemporal sequence recognition and prediction in primary visual cortex
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Learned spatiotemporal sequence recognition and prediction in primary visual cortex
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Journal Article
Learned spatiotemporal sequence recognition and prediction in primary visual cortex
2014
Overview
Here the authors report that repeated presentations of a visual sequence over a course of days causes evoked response potentiation in mouse V1 that is highly specific for stimulus order and timing. After V1 is trained to recognize a sequence, cortical activity regenerates the full sequence even when individual stimulus elements are omitted.
Learning to recognize and predict temporal sequences is fundamental to sensory perception and is impaired in several neuropsychiatric disorders, but little is known about where and how this occurs in the brain. We discovered that repeated presentations of a visual sequence over a course of days resulted in evoked response potentiation in mouse V1 that was highly specific for stimulus order and timing. Notably, after V1 was trained to recognize a sequence, cortical activity regenerated the full sequence even when individual stimulus elements were omitted. Our results advance the understanding of how the brain makes 'intelligent guesses' on the basis of limited information to form visual percepts and suggest that it is possible to study the mechanistic basis of this high-level cognitive ability by studying low-level sensory systems.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ 64/60
/ 9/30
/ Animal Genetics and Genomics
/ Animals
/ Cholinergic Antagonists - pharmacology
/ Evoked Potentials, Visual - drug effects
/ Evoked Potentials, Visual - physiology
/ Excitatory Amino Acid Antagonists - pharmacology
/ Male
/ Mice
/ Rapid serial visual presentation
/ Recognition (Psychology) - physiology
/ Scopolamine Hydrobromide - pharmacology
/ Serial Learning - drug effects
/ Serial Learning - physiology
/ Visual Cortex - drug effects
/ Visual Pathways - drug effects
