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Suppression of tumor growth and metastasis in Mgat5-deficient mice
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Suppression of tumor growth and metastasis in Mgat5-deficient mice
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Suppression of tumor growth and metastasis in Mgat5-deficient mice
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Journal Article
Suppression of tumor growth and metastasis in Mgat5-deficient mice
2000
Overview
Golgi β1,6N-acetylglucosaminyltransferase V (MGAT5) is required in the biosynthesis of β1,6GlcNAc-branched N-linked glycans attached to cell surface and secreted glycoproteins. Amounts of MGAT5 glycan products are commonly increased in malignancies, and correlate with disease progression. To study the functions of these N-glycans in development and disease, we generated mice deficient in Mgat5 by targeted gene mutation. These
Mgat5
−/−
mice lacked Mgat5 products and appeared normal, but differed in their responses to certain extrinsic conditions. Mammary tumor growth and metastases induced by the polyomavirus middle T oncogene was considerably less in
Mgat5
−/−
mice than in transgenic littermates expressing Mgat5. Furthermore, Mgat5 glycan products stimulated membrane ruffling and phosphatidylinositol 3 kinase–protein kinase B activation, fueling a positive feedback loop that amplified oncogene signaling and tumor growth
in vivo
. Our results indicate that inhibitors of MGAT5 might be useful in the treatment of malignancies by targeting their dependency on focal adhesion signaling for growth and metastasis.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Animals
/ b-1,6-N-acetylglucosaminyltransferase V
/ b1,6N-acetylglucosaminyltransferase V
/ Biomedical and Life Sciences
/ Cancer
/ Enzymes
/ Female
/ Golgi Apparatus - metabolism
/ Humans
/ Kinases
/ Lectins
/ Male
/ Mammary Neoplasms, Experimental - pathology
/ Mammary Neoplasms, Experimental - prevention & control
/ Mice
/ Motility
/ Mutation
/ N-Acetylglucosaminyltransferases - deficiency
/ N-Acetylglucosaminyltransferases - genetics
/ N-Acetylglucosaminyltransferases - metabolism
/ Polysaccharides - biosynthesis
/ Recombinant Proteins - metabolism
/ Tumors
