Journal Article

Association of the visceral fat metabolic score with osteoarthritis risk: a cross-sectional study from NHANES 2009–2018

Jiang, Lingling, Xu, Jiankang, Zhang, Longyao, Zhang, Chao, Gao, Kuiliang, Lv, Sirui, Xue, Hongfei

2024

Overview

Background Currently, obesity has been recognized to be an independent risk factor for osteoarthritis (OA), and the Metabolic Score for Visceral Fat (METS-VF) has been suggested to be potentially more accurate than body mass index (BMI) in the assessment of obesity. Nevertheless, the correlation of METS-VF with OA has not been obviously revealed yet. Therefore, this study aimed to delve into the potential relationship between METS-VF and OA. Methods By examining data from the NHANES (2009–2018), weighted multivariate logistic regression analyses were used for assessing the correlation between METS-VF and OA. Subgroup analyses were then performed to validate the findings. Moreover, the nonlinear relationship between the two was assessed by restricted cubic spline (RCS). Receiver operating characteristic (ROC) curves were plotted to examine the diagnostic accuracy of METS-VF versus previous obesity index for OA. Results This study involved 7639 participants. According to our results, METS-VF was notably related to an elevated risk of OA, regardless of the METS-VF and the trend of positive association was more pronounced with the elevating METS-VF level (p for trend < 0.05). Subgroup analyses showed that the positive association between METS-VF and prevalence of osteoarthritis persisted in all populations with different characteristics, confirming its validity in all populations. Besides, RCS results showed a significant non-linear relationship between METS-VF and OA (p-non-linear < 0.05). As indicated by the ROC curve analysis results, METS-VF was a superior predictor of OA to BMI and HC. Conclusions This study finds a possible nonlinear positive correlation between METS-VF and the risk of OA. In addition, METS-VF may serve as an indicator for the more accurate diagnosis of OA and provide a new way to further evaluate the relationship between visceral fat and OA.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Adult / Age / Aged / Alcohol / Alcohol use / Analysis / Arthritis / Biostatistics / Blood pressure / Body Mass Index / Body size / Cardiovascular disease / Correlation / Cross-Sectional Studies / Diabetes / Diagnosis / Education / Energy intake / Environmental Health / Epidemiology / Fat cells / Fat metabolism / Fatty acids / Female / Females / Gender / Health aspects / Humans / Hypertension / Intra-Abdominal Fat - metabolism / Male / Medical laboratories / Medicine / Medicine & Public Health / Metabolic Syndrome - epidemiology / Metabolism / METS-VF / Middle Aged / Multivariate analysis / NHANES / Nutrition Surveys / Obesity / Obesity - epidemiology / Osteoarthritis / Osteoarthritis - epidemiology / Osteoarthritis - metabolism / Populations / Public Health / Questionnaires / Regression analysis / Risk Factors / Secondary schools / Smoking / Subgroups / United States - epidemiology / Vaccine / Visceral fat metabolism