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Clonal diversity of Haemophilus influenzae carriage isolated from under the age of 6 years children
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Clonal diversity of Haemophilus influenzae carriage isolated from under the age of 6 years children
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Journal Article
Clonal diversity of Haemophilus influenzae carriage isolated from under the age of 6 years children
2019
Overview
Objectives
Pharyngeal carriers such as
H
.
influenzae
seem to constitute the only reservoir and probably the only transmission vehicle of the invasive disease. The aims of this study were to estimate the prevalence of
H. influenzae
carriage, to characterize antibiotic susceptibility, and to explore genetic diversity of
H. influenzae
isolates. Sampling was carried out as nasopharynx swabs among children less than 6 years old volunteers. After traditional biochemical tests, isolates were confirmed by targeting
omp6
sequence. Following the susceptibility tests, genomic diversity of strains was analyzed by Pulsed-Field Gel Electrophoresis procedure.
Results
Out of 328 nasopharynx swabs, 73 strains were identified as H.
influenzae
. Among
H. influenzae
isolates, resistance to chloramphenicol (42%) and ampicillin (43%) was observed. Levofloxacin is the most effective antibiotic and the least effect belonged to tetracycline. By genomic analysis of selected
H
.
influenza
, 28 PFGE patterns were achieved among which 11 patterns included at least 2 strains. All strains clustered into 25 different clones. The dendrogram analysis of the isolated
H
.
influenzae
strains showed that some of these strains had a clonal relationship and common genetic origin. According to our results, antibiotic resistance didn’t show any significant correlation with the clonality of strains.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Anti-Bacterial Agents - therapeutic use
/ Bacteria
/ Biomedical and Life Sciences
/ Carrier state (Communicable diseases)
/ Carrier State - drug therapy
/ Carrier State - epidemiology
/ Carrier State - microbiology
/ Children
/ Cloning
/ DNA
/ Electrophoresis, Gel, Pulsed-Field
/ Female
/ Haemophilus Infections - drug therapy
/ Haemophilus Infections - epidemiology
/ Haemophilus Infections - microbiology
/ Haemophilus influenzae - classification
/ Haemophilus influenzae - genetics
/ Haemophilus influenzae - physiology
/ Humans
/ Male
/ Microbial Sensitivity Tests - methods
/ Pediatric communicable diseases
/ PFGE
/ Pharynx
/ Pulsed-field gel electrophoresis
/ Testing
