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Distinct progenitor lineages contribute to the heterogeneity of plasmacytoid dendritic cells
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Distinct progenitor lineages contribute to the heterogeneity of plasmacytoid dendritic cells
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Journal Article
Distinct progenitor lineages contribute to the heterogeneity of plasmacytoid dendritic cells
2018
Overview
Plasmacytoid dendritic cells (pDCs) are an immune subset devoted to the production of high amounts of type 1 interferons in response to viral infections. Whereas conventional dendritic cells (cDCs) originate mostly from a common dendritic cell progenitor (CDP), pDCs have been shown to develop from both CDPs and common lymphoid progenitors. Here, we found that pDCs developed predominantly from IL-7R
+
lymphoid progenitor cells. Expression of SiglecH and Ly6D defined pDC lineage commitment along the lymphoid branch. Transcriptional characterization of SiglecH
+
Ly6D
+
precursors indicated that pDC development requires high expression of the transcription factor IRF8, whereas pDC identity relies on TCF4. RNA sequencing of IL-7R
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lymphoid and CDP-derived pDCs mirrored the heterogeneity of mature pDCs observed in single-cell analysis. Both mature pDC subsets are able to secrete type 1 interferons, but only myeloid-derived pDCs share with cDCs their ability to process and present antigen.
Tussiwand and colleagues show that pDCs develop predominantly from IL-7R
+
lymphoid progenitor cells and that mature pDCs are transcriptionally and functionally heterogenous, on the basis of their lymphoid or myeloid lineage.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Animals
/ Antigens
/ B cells
/ Biomedical and Life Sciences
/ Dendritic Cells - immunology
/ Female
/ GTPase-Activating Proteins - metabolism
/ Interferon Regulatory Factors - metabolism
/ Male
/ Mice
/ Receptors, Cell Surface - metabolism
/ Receptors, Interleukin-7 - metabolism
/ RNA
