Journal Article

Biological evaluation of Safrole oil and Safrole oil Nanoemulgel as antioxidant, antidiabetic, antibacterial, antifungal and anticancer

Hawash, Mohammed, Eid, Ahmad M.

2021

Overview

Background Safrole is a natural compound extracted from various plants, and has shown various biological activities. The current study aimed to investigate the antioxidant, antidiabetic, antimicrobial, and anticancer activity of safrole oil and to study the influence of safrole nanoemulgel on these activities. Methods The antioxidant and antidiabetic in-vitro assays were conducted using standard biomedical methods. The safrole oil nanoemulgel was developed using a self-emulsifying technique. Then the antimicrobial activity of the safrole oil and safrole nanoemulgel were performed on different microbial species, and cytotoxicity was determined against Hep3B cancer cell lines using the MTS assay. Results Safrole oil showed moderate antioxidant activity compared with standard Trolox, with IC 50 value 50.28 ± 0.44 and 1.55 ± 0.32 μg/ml, respectively. Moreover, it had potent α-amylase inhibitory activity (IC 50 11.36 ± 0.67 μg/ml) compared with Acarbose (IC 50 value 5.88 ± 0.63). The safrole nanoemulgel had pseudo-plastic behaviour, droplet sizes below 200 nm, a polydispersity index (PDI) below 0.3, and a zeta potential of less than − 30 mV. Safrole oil has potential antimicrobial and anticancer activities, and these activities were improved with safrole nanoemulgel. Conclusion The safrole oil may be applied for the prevention and treatment of oxidative stress, diabetes, different microbial species and cancer, and these activities could be improved by nano-carriers.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Acarbose / Acids / alpha-amylase / Alternative medicine / Anti-Infective Agents - analysis / Anti-Infective Agents - chemistry / Anti-Infective Agents - pharmacology / Antibacterial agents / Anticancer and Nanoemulgel / Anticancer properties / Antidiabetic / Antidiabetics / Antifungal agents / Antiinfectives and antibacterials / Antimicrobial / Antimicrobial activity / Antimicrobial agents / antimicrobial properties / antineoplastic activity / Antineoplastic Agents - analysis / Antineoplastic Agents - chemistry / Antineoplastic Agents - pharmacology / Antioxidant / antioxidant activity / Antioxidants / Antioxidants - analysis / Antioxidants - chemistry / Antioxidants - pharmacology / Antitumor activity / Basic research / Biocompatibility / biological assessment / Biphenyl Compounds - chemistry / Biphenyl Compounds - metabolism / Cancer / Care and treatment / Cell Line, Tumor / Cell Survival - drug effects / Chiropractic Medicine / Comparative analysis / complement / Complementary & Alternative Medicine / Cytotoxicity / Diabetes / Diabetes mellitus / droplets / Drug delivery systems / Drug dosages / Enzymes / Fungicides / Humans / Hydrogels / Hypoglycemic Agents - analysis / Hypoglycemic Agents - chemistry / Hypoglycemic Agents - pharmacology / Internal Medicine / Medicine / Medicine & Public Health / Microorganisms / nanocarriers / Nanoemulsions / Nanostructures - analysis / Nanostructures - chemistry / Nanotechnology / neoplasm cells / Oil / oils / Oils, Volatile - analysis / Oils, Volatile - chemistry / Oils, Volatile - pharmacology / Oxidative stress / Particle Size / Pharmaceutical industry / Picrates - chemistry / Picrates - metabolism / Plant extracts / Plasticity / Polydispersity / Pseudoplasticity / Research Article / Safrole / Safrole - analysis / Safrole - chemistry / Safrole - pharmacology / Safrole oil / species / Surfactants / Toxicity / Tumor cell lines / Vitamin E / Zeta potential / α-Amylase