Journal Article

Ventriculoperitoneal shunt patients and glaucoma: a cohort analysis of the NPH registry

Kemiläinen, Benjam, Kaarniranta, Kai, Leinonen, Ville

2024

Overview

Background Idiopathic Normal Pressure Hydrocephalus (iNPH) is a chronic condition affecting the elderly. It is characterized by a triad of symptoms and radiological findings. Glaucoma is the leading cause of irreversible blindness worldwide. Earlier studies have proposed that the rate of glaucoma is higher in iNPH patients, and of a possible link between ventriculoperitoneal shunt (VP) treatment and the development of glaucoma. Objectives This study aimed to determine the prevalence of glaucoma among iNPH patients and assess the impact of VPs on glaucoma prevalence. Methods A cohort study was conducted at Kuopio University Hospital (KUH), including 262 patients with a ventriculoperitoneal shunt. Clinical data were obtained from the Kuopio NPH Registry and medical records. Patients were grouped by iNPH status: iNPH (+) – probable/possible iNPH ( n  = 192), and iNPH (-) – other causes of hydrocephalus (congenital, secondary, obstructive) ( n  = 70). We conducted statistical analysis using the Independent Samples T-test, Fisher’s exact test, and Pearson Chi-Square. We compared demographics, glaucoma prevalence, brain biopsies positive for Amyloid-β (Aβ) and hyperphosphorylated tau (HPτ) as well as comorbidities for hypertension and diabetes medication. Age stratification assessed glaucoma prevalence in the full cohort. Results Both iNPH (+) and iNPH (-) groups had comparable demographic and comorbidity profiles. The prevalence of glaucoma in the iNPH (+) group was 11.5% ( n  = 22) and 11.4% ( n  = 8) in the iNPH (-) group without a statistically significant difference ( p  = 1.000). Brain biopsies positive for Amyloid-β (Aβ) and hyperphosphorylated tau (HPτ) were similar. Conclusions Neither shunted iNPH patients nor those with a comorbid condition other than iNPH showed a markedly higher prevalence of glaucoma. Instead, both groups exhibited age-related increases in glaucoma prevalence, similar to the trends observed in population-based studies. Our data does not suggest a correlation between VP shunts and an elevated rate of glaucoma.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Age / Aged / Aged, 80 and over / Amyloid-β / Biomedical and Life Sciences / Biomedicine / Biopsy / Blindness / Brain research / Care and treatment / Cohort analysis / Cohort Studies / Comorbidity / Demographics / Demography / Diabetes / Diabetes mellitus / Executives / Female / Genetic disorders / Glaucoma / Glaucoma - epidemiology / Hematology / Humans / Hydrocephalus / Hydrocephalus, Normal Pressure - epidemiology / Hydrocephalus, Normal Pressure - surgery / Hyperphosphorylated tau / Hypertension / Hypoglycemic agents / Idiopathic normal pressure hydrocephalus / Independent sample / Information systems / Male / Males / Medical records / Medical research / Medicine, Experimental / Middle Aged / Neurobiology / Neurosciences / Older people / Patients / Population / Population studies / Prevalence / Registries / Shunts / Sleep apnea / Statistical analysis / Type 2 diabetes / Ventriculoperitoneal shunt / Ventriculoperitoneal Shunt - adverse effects / β-Amyloid