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Prevalence and influencing factors of nonunion in patients with tibial fracture: systematic review and meta-analysis
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Prevalence and influencing factors of nonunion in patients with tibial fracture: systematic review and meta-analysis
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Prevalence and influencing factors of nonunion in patients with tibial fracture: systematic review and meta-analysis
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Journal Article
Prevalence and influencing factors of nonunion in patients with tibial fracture: systematic review and meta-analysis
2020
Overview
Objective
The aim of this study is to assess the prevalence of nonunion in patients with tibia fracture and the association between influencing factors and tibia fracture nonunion.
Method
A database searches of PubMed, the Cochrane Library, EMBASE, China National Knowledge Infrastructure (CNKI), Weipu database, and Wanfang database from inception until June 2019 was conducted. The pooled prevalence, odds ratio (OR), and 95% confidence intervals (CI) were calculated with Stata software.
Results
In this study, 111 studies involving 41,429 subjects were included. In the study of the relationship between influencing factors and tibia fracture nonunion, 15 factors significantly influenced the fracture union, including > 60 years old, male, tobacco smoker, body mass index > 40, diabetes, nonsteroidal anti-inflammatory drugs (NSAIDs) user, opioids user, fracture of middle and distal tibia, high-energy fracture, open fracture, Gustilo-Anderson grade IIIB or IIIC, Müller AO Classification of Fractures C, open reduction, fixation model, and infection.
Conclusion
The prevalence of nonunion in patients with tibia fracture was 0.068 and 15 potential factors were associated with the prevalence. Closed reduction and minimally invasive percutaneous plate osteosynthesis (MIPPO) have the low risks of nonunion for the treatment of tibial fractures.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Adult
/ Aged
/ Analysis
/ Anti-Inflammatory Agents, Non-Steroidal
/ Bias
/ Closed Fracture Reduction - methods
/ Diabetes
/ Female
/ Fracture Fixation, Internal - methods
/ Fractures, Ununited - epidemiology
/ Fractures, Ununited - etiology
/ Fractures, Ununited - surgery
/ Humans
/ Male
/ Medicine
/ Minimally Invasive Surgical Procedures - methods
/ Nonsteroidal anti-inflammatory drugs
/ Nonunion
/ Opioids
/ Prevalence studies (Epidemiology)
/ Smoking
/ Tibia
/ Tibial Fractures - epidemiology
/ Tobacco
