Asset Details
Do you wish to reserve the book?
p-Tolyl isocyanate derivatization for analysis of CWC-related polar degradation products by mass spectrometry
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
p-Tolyl isocyanate derivatization for analysis of CWC-related polar degradation products by mass spectrometry
Do you wish to request the book?
p-Tolyl isocyanate derivatization for analysis of CWC-related polar degradation products by mass spectrometry
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
p-Tolyl isocyanate derivatization for analysis of CWC-related polar degradation products by mass spectrometry
2014
Overview
Most of the precursors and/or degradation products related to the Chemical Weapons Convention (CWC) are polar. Identification of these molecules in environmental samples provides clues regarding the alleged usage and/or synthesis of the parent toxic chemicals. Such polar compounds need to be derivatized in order to analyze them by gas chromatography–mass spectrometry (GC–MS). In this study, we developed a new derivatizing reagent,
para
-tolyl isocyanate (PTI), for derivatization of polar CWC-related compounds. The PTI reagent selectively derivatizes the –OH and/or−SH functional groups with high efficiency, but does not react with carboxylic acid (−COOH) or phosphonic acid (−(O)P(OH)
2
) groups. The PTI derivatives of dialkyl aminoethanols, dialkyl aminoethanol-
N
-oxides, and 3-quinuclidinol were successfully eluted through GC, and their electron ionization (EI) mass spectra were distinct and provided the structure information by which the isomeric compounds can be easily distinguished. We also calculated the GC-retention index values that can be used for further confirmation of the target compounds. All the studied PTI derivatives can be analyzed by EI-MS with direct insertion probe and/or by direct electrospray ionization mass spectrometry (ESI-MS) together with the MS–MS data; both sets of data provide full structure information. The PTI reagent was found to be better in some respects than the conventional bistrimethylsilyl trifluoroacetamide (BSTFA), a trimethyl silylating reagent. The PTI reagent is commercially available, and the PTI derivatives are highly stable for months and are not sensitive to moisture. The applicability of the PTI derivatization for trace-level determination of the target CWC-related polar compounds in environmental matrices and in human plasma samples is also evaluated.
Fig. a
ᅟ
Publisher
Springer Berlin Heidelberg,Springer,Springer Nature B.V
Subject
/ alcohols
/ amides
/ amines
/ Analysis
/ Analysis of Chemicals Relevant to the Chemical Weapons Convention
/ Biological & chemical weapons
/ Characterization and Evaluation of Materials
/ Chemical Warfare Agents - chemistry
/ Chemical Warfare Agents - isolation & purification
/ Chemistry and Materials Science
/ electrospray ionization mass spectrometry
/ gas chromatography-mass spectrometry
/ Gas Chromatography-Mass Spectrometry - methods
/ Humans
/ Monitoring/Environmental Analysis
/ Phenols
/ Reagents
/ Solvents
/ Spectrometry, Mass, Electrospray Ionization
/ Sulfhydryl Compounds - chemistry
/ thiols
/ Toxicity
/ Toxins
/ Weapons
