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Sexually dimorphic gastrin releasing peptide system in the spinal cord controls male reproductive functions
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Sexually dimorphic gastrin releasing peptide system in the spinal cord controls male reproductive functions
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Journal Article
Sexually dimorphic gastrin releasing peptide system in the spinal cord controls male reproductive functions
2008
Overview
Neurons in the upper lumbar spinal cord project axons containing gastrin-releasing peptide (GRP) to innervate lower lumbar regions controlling erection and ejaculation. This system is vestigial in female rats and in males with genetic dysfunction of androgen receptors, but in male rats, pharmacological stimulation of spinal GRP receptors restores penile reflexes and ejaculation after castration. GRP offers new avenues for understanding potential therapeutic approaches to masculine reproductive dysfunction.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
Androgen-Insensitivity Syndrome - genetics
/ Animal Genetics and Genomics
/ Animals
/ Biomedical and Life Sciences
/ Bombesin - analogs & derivatives
/ Dose-Response Relationship, Drug
/ Female
/ Females
/ Gastrin-Releasing Peptide - pharmacology
/ Gastrin-Releasing Peptide - physiology
/ Horseradish Peroxidase - metabolism
/ Male
/ Males
/ Neurons
/ Nitric Oxide Synthase Type I - metabolism
/ Penile Erection - drug effects
/ Penile Erection - physiology
/ Penis
/ Peptide Fragments - pharmacology
/ Peptides
/ Protein Binding - drug effects
/ Rats
/ Reaction Time - drug effects
