Journal Article

Evaluation of the Pfs25-IMX313/Matrix-M malaria transmission-blocking candidate vaccine in endemic settings

Williams, Chris, Mulamba, Charles, Kreppel, Katharina, Ouedraogo, Jean Bosco, Olotu, Ally I.

2022

Overview

Malaria control relies heavily on the use of anti-malarial drugs and insecticides against malaria parasites and mosquito vectors. Drug and insecticide resistance threatens the effectiveness of conventional malarial interventions; alternative control approaches are, therefore, needed. The development of malaria transmission-blocking vaccines that target the sexual stages in humans or mosquito vectors is among new approaches being pursued. Here, the immunological mechanisms underlying malaria transmission blocking, status of Pfs25-based vaccines are viewed, as well as approaches and capacity for first in-human evaluation of a transmission-blocking candidate vaccine Pfs25-IMX313/Matrix-M administered to semi-immune healthy individuals in endemic settings. It is concluded that institutions in low and middle income settings should be supported to conduct first-in human vaccine trials in order to stimulate innovative research and reduce the overdependence on developed countries for research and local interventions against many diseases of public health importance.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Antigens / Aquatic insects / Biomedical and Life Sciences / Biomedicine / Developed countries / Disease control / Disease transmission / Entomology / Health aspects / Human diseases / Immunosuppressive agents / Infections / Infectious Diseases / Insecticide resistance / Insecticides / Malaria / Malaria vaccine / Microbiology / Mortality / Mosquitoes / Parasites / Parasitology / Pesticide resistance / Plasmodium falciparum / Prevention / Proteins / Public Health / Regulatory approval / Review / Risk factors / Sexual stages / Testing / Transmission-blocking vaccines / Tropical Medicine / Vaccines / Vector-borne diseases / Vectors