Journal Article

Striatal activity topographically reflects cortical activity

Fabre, Julie M. J., Steinmetz, Nicholas A., Peters, Andrew J., Harris, Kenneth D., Carandini, Matteo

2021

Overview

The cortex projects to the dorsal striatum topographically 1 , 2 to regulate behaviour 3 – 5 , but spiking activity in the two structures has previously been reported to have markedly different relations to sensorimotor events 6 – 9 . Here we show that the relationship between activity in the cortex and striatum is spatiotemporally precise, topographic, causal and invariant to behaviour. We simultaneously recorded activity across large regions of the cortex and across the width of the dorsal striatum in mice that performed a visually guided task. Striatal activity followed a mediolateral gradient in which behavioural correlates progressed from visual cue to response movement to reward licking. The summed activity in each part of the striatum closely and specifically mirrored activity in topographically associated cortical regions, regardless of task engagement. This relationship held for medium spiny neurons and fast-spiking interneurons, whereas the activity of tonically active neurons differed from cortical activity with stereotypical responses to sensory or reward events. Inactivation of the visual cortex abolished striatal responses to visual stimuli, supporting a causal role of cortical inputs in driving the striatum. Striatal visual responses were larger in trained mice than untrained mice, with no corresponding change in overall activity in the visual cortex. Striatal activity therefore reflects a consistent, causal and scalable topographical mapping of cortical activity. Simultaneous mapping of activity across the cortex and dorsal striatum in mice shows that activity in each part of the striatum precisely mirrors that in topographically associated cortical regions, consistently across behavioural contexts.

• Publisher: Nature Publishing Group UK,Nature Publishing Group
• Subject: 59/5 / 631/378/2629/1409 / 631/378/2632/1323 / 64/60 / 9/10 / Animal behavior / Animals / Caudate-putamen / Cerebral cortex / Cerebral Cortex - cytology / Cerebral Cortex - physiology / Corpus striatum / Corpus Striatum - cytology / Corpus Striatum - physiology / Female / Firing pattern / Humanities and Social Sciences / Inactivation / Interneurons / Interneurons - metabolism / Learning / Male / Mice / multidisciplinary / Neostriatum / Neurons / Neurons - metabolism / Photic Stimulation / Physiological aspects / Psychomotor Performance / Reinforcement / Reward / Science / Science (multidisciplinary) / Sensorimotor Cortex - physiology / Sensorimotor system / Somatosensory cortex / Spiking / Spiny neurons / Topographic mapping / Visual cortex / Visual Cortex - physiology / Visual stimuli