Journal Article

Genetic predisposition to uterine leiomyoma is determined by loci for genitourinary development and genome stability

Välimäki, Niko, Tanskanen, Tomas, Uimari, Outi, Palin, Kimmo, Heikinheimo, Oskari, Aaltonen, Lauri A, Bramante, Simona, Auvinen, Juha, Heinonen, Hanna-Riikka, Bützow, Ralf, Kaasinen, Eevi, Kuisma, Heli, Pasanen, Annukka, Sjöberg, Jari, Lehtonen, Rainer, Tolvanen, Jaana, Alkodsi, Amjad, Sarvilinna, Nanna

2018

Overview

Uterine leiomyomas (ULs) are benign tumors that are a major burden to women’s health. A genome-wide association study on 15,453 UL cases and 392,628 controls was performed, followed by replication of the genomic risk in six cohorts. Effects of the risk alleles were evaluated in view of molecular and clinical characteristics. 22 loci displayed a genome-wide significant association. The likely predisposition genes could be grouped to two biological processes. Genes involved in genome stability were represented by TERT, TERC, OBFC1 - highlighting the role of telomere maintenance - TP53 and ATM. Genes involved in genitourinary development, WNT4, WT1, SALL1, MED12, ESR1, GREB1, FOXO1, DMRT1 and uterine stem cell marker antigen CD44, formed another strong subgroup. The combined risk contributed by the 22 loci was associated with MED12 mutation-positive tumors. The findings link genes for uterine development and genetic stability to leiomyomagenesis, and in part explain the more frequent occurrence of UL in women of African origin. Fibroids – also known as uterine leiomyomas, or myomas – are a very common form of benign tumor that grows in the muscle wall of the uterus. As many as 70% of women develop fibroids in their lifetime. About a fifth of women report symptoms including severe pain, heavy bleeding during periods and complications in pregnancy. In the United States, the cost of treating fibroids is estimated to be $34 billion each year. Despite the prevalence of fibroids in women, there are few treatments available. Drugs to target them have limited effect and often an invasive procedure such as surgery is needed to remove the tumors. However, a better understanding of the genetics of fibroids could lead to a way to develop better treatment options. Välimäki, Kuisma et al. used a genome-wide association study to seek out DNA variations that are more common in people with fibroids. Using data from the UK Biobank, the genomes of over 15,000 women with fibroids were analyzed against a control population of over 392,000 individuals. The analysis revealed 22 regions of the genome that were associated with fibroids. These regions included genes that may well contribute to fibroid development, such as the gene TP53, which influences the stability of the genome, and ESR1, which codes for a receptor for estrogen – a hormone known to play a role in the growth of fibroids. Variation in a set of genes known to control development of the female reproductive organs was also identified in women with fibroids. The findings are the result of the largest genome-wide association study on fibroids, revealing a set of genes that could influence the development of fibroids. Studying these genes could lead to more effective drug development to treat fibroids. Revealing this group of genes could also help to identify women at high risk of developing fibroids and help to prevent or manage the condition.

• Publisher: eLife Science Publications, Ltd,eLife Sciences Publications Ltd,eLife Sciences Publications, Ltd
• Subject: Alleles / Analysis / Antigens / Biochemistry / Biology / Cancer / CD44 antigen / Chromosomes / DNA / DNA methylation / ESR1 protein / Estrogens / Female / Fibroids / FOXO1 protein / Gene expression / Gene loci / Genes / Genetic Loci / Genetic Predisposition to Disease / Genetic research / Genetics and Genomics / Genitalia / Genome-wide association studies / Genome-Wide Association Study / Genomes / Genomic Instability / Genomics / Gynecology / Health / Hormones / Hospitals / Humans / Kinases / Leiomyoma / Leiomyoma - genetics / leiomyomagenesis / Meta-analysis / Morphogenesis / Muscle tissue tumors / Mutation / Obstetrics / p53 Protein / Phenols (Class of compounds) / Proteins / Risk Assessment / Stem cells / Surgery / Telomerase / Telomeres / Transcription factors / Tumor proteins / Tumors / uterine leiomyoma / Uterine Neoplasms - genetics / Uterus / Uterus - growth & development / Wnt protein / Women / Women's health