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3D-printed hydrogel particles containing PRP laden with TDSCs promote tendon repair in a rat model of tendinopathy

by Li, Congsun , Yu, Kang , Hong, Jianqiao , Yan, Shigui , Ma, Chiyuan , Yang, Weinan , Jiang, Guangyao , Chen, Yazhou , Wu, Haobo , Wang, Jie , Yao, Minjun , Yu, Xiaohua , Liu, An , Li, Sihao , Ji, Xiaoxiao , Lu, Jinwei

in 1-Phosphatidylinositol 3-kinase / 3-D printers / 3D printing / Achilles tendon / AKT protein / Animals / Biotechnology / Care and treatment / Cell growth / Chemistry / Chemistry and Materials Science / Diagnosis / Ethylenediaminetetraacetic acid / Gels (Pharmacy) / Health aspects / Homeostasis / Hydrogel / Hydrogels / Hydrogels - pharmacology / Inflammation / Inflammatory response / Leukocytes / Methods / Microparticles / Molecular Medicine / Morphology / Nanotechnology / Phosphatidylinositol 3-Kinases - metabolism / PI3K-AKT pathway / Platelet-Rich Plasma - metabolism / Printing, Three-Dimensional / Rats / Stem Cells / Structure-function relationships / Surgery / TDSCs / Tendinopathy / Tendinopathy - metabolism / Tendinopathy - therapy / Tendon injuries / Tendons / Three dimensional printing / Tissue engineering / Wound healing

2023

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3D-printed hydrogel particles containing PRP laden with TDSCs promote tendon repair in a rat model of tendinopathy

2023

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3D-printed hydrogel particles containing PRP laden with TDSCs promote tendon repair in a rat model of tendinopathy

2023

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Journal Article

3D-printed hydrogel particles containing PRP laden with TDSCs promote tendon repair in a rat model of tendinopathy

Li, Congsun,

Yu, Kang,

Hong, Jianqiao,

Yan, Shigui,

Ma, Chiyuan,

Yang, Weinan,

Jiang, Guangyao,

Chen, Yazhou,

Wu, Haobo,

Wang, Jie,

Yao, Minjun,

Yu, Xiaohua,

Liu, An,

Li, Sihao,

Ji, Xiaoxiao,

Lu, Jinwei

2023

Overview

Long-term chronic inflammation after Achilles tendon injury is critical for tendinopathy. Platelet-rich plasma (PRP) injection, which is a common method for treating tendinopathy, has positive effects on tendon repair. In addition, tendon-derived stem cells (TDSCs), which are stem cells located in tendons, play a major role in maintaining tissue homeostasis and postinjury repair. In this study, injectable gelatine methacryloyl (GelMA) microparticles containing PRP laden with TDSCs (PRP–TDSC–GM) were prepared by a projection-based 3D bioprinting technique. Our results showed that PRP–TDSC–GM could promote tendon differentiation in TDSCs and reduce the inflammatory response by downregulating the PI3K–AKT pathway, thus promoting the structural and functional repair of tendons in vivo. Graphical Abstract

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Publisher

BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC

Subject

1-Phosphatidylinositol 3-kinase

/ Animals