Asset Details
Do you wish to reserve the book?
Lessons from human teratomas to guide development of safe stem cell therapies
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Lessons from human teratomas to guide development of safe stem cell therapies
Do you wish to request the book?
Lessons from human teratomas to guide development of safe stem cell therapies
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Lessons from human teratomas to guide development of safe stem cell therapies
2012
Overview
The potential for the formation of teratomas or other neoplasms is a major safety roadblock to clinical application of pluripotent stem cell therapies. Preclinical assessment of the risk of tumor formation in this context poses considerable scientific and regulatory challenges, especially because animal xenograft models may not properly reflect the long-term tumorigenic potential of human cells. A better understanding of the biology of spontaneously occurring teratomas and related tumors in humans can help to guide efforts to assess and minimize the potential hazards of embryonic stem cell or induced pluripotent stem cell therapeutics. Here we review the features of teratomas derived experimentally from human pluripotent stem cells and argue that they most closely resemble spontaneous benign teratomas that occur early in both mouse and human life. The natural history and pathology of these spontaneously occurring teratomas provide important clues for preclinical safety assessment and patient monitoring in trials of stem cell therapies.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Animals
/ Biomedical and Life Sciences
/ Biomedical Engineering/Biotechnology
/ Cancer
/ Female
/ Humans
/ Male
/ Mice
/ Pluripotent Stem Cells - pathology
/ Safety
/ Stem Cell Transplantation - adverse effects
/ Stem Cell Transplantation - methods
/ Stem Cell Transplantation - standards
/ Teratoma
/ Therapy
/ Tumors
